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Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
Schistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). Howeve...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282181/ https://www.ncbi.nlm.nih.gov/pubmed/34277472 http://dx.doi.org/10.3389/fcimb.2021.691757 |
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author | Wu, Kaijuan Zhai, Xingyu Huang, Shuaiqin Jiang, Liping Yu, Zheng Huang, Jing |
author_facet | Wu, Kaijuan Zhai, Xingyu Huang, Shuaiqin Jiang, Liping Yu, Zheng Huang, Jing |
author_sort | Wu, Kaijuan |
collection | PubMed |
description | Schistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). However, PZQ exhibits low killing efficacy on juvenile worms and the potential emergence of its drug resistance is a continual concern. Protein kinases (PKs) are enzymes that catalyze the phosphorylation of proteins and can participate in many signaling pathways in vivo. Recent studies confirmed the essential roles of PKs in the growth and development of S. japonicum, as well as in schistosome-host interactions, and researches have screened drug targets about PKs from S. japonicum (SjPKs), which provide new opportunities of developing new treatments on schistosomiasis. The aim of this review is to present the current progress on SjPKs from classification, different functions and their potential to become drug targets compared with other schistosomes. The efficiency of related protein kinase inhibitors on schistosomes is highlighted. Finally, the current challenges and problems in the study of SjPKs are proposed, which can provide future guidance for developing anti-schistosomiasis drugs and vaccines. |
format | Online Article Text |
id | pubmed-8282181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82821812021-07-16 Protein Kinases: Potential Drug Targets Against Schistosoma japonicum Wu, Kaijuan Zhai, Xingyu Huang, Shuaiqin Jiang, Liping Yu, Zheng Huang, Jing Front Cell Infect Microbiol Cellular and Infection Microbiology Schistosoma japonicum (S. japonicum) infection can induce serious organ damage and cause schistosomiasis japonica which is mainly prevalent in Asia and currently one of the most seriously neglected tropical diseases. Treatment of schistosomiasis largely depends on the drug praziquantel (PZQ). However, PZQ exhibits low killing efficacy on juvenile worms and the potential emergence of its drug resistance is a continual concern. Protein kinases (PKs) are enzymes that catalyze the phosphorylation of proteins and can participate in many signaling pathways in vivo. Recent studies confirmed the essential roles of PKs in the growth and development of S. japonicum, as well as in schistosome-host interactions, and researches have screened drug targets about PKs from S. japonicum (SjPKs), which provide new opportunities of developing new treatments on schistosomiasis. The aim of this review is to present the current progress on SjPKs from classification, different functions and their potential to become drug targets compared with other schistosomes. The efficiency of related protein kinase inhibitors on schistosomes is highlighted. Finally, the current challenges and problems in the study of SjPKs are proposed, which can provide future guidance for developing anti-schistosomiasis drugs and vaccines. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8282181/ /pubmed/34277472 http://dx.doi.org/10.3389/fcimb.2021.691757 Text en Copyright © 2021 Wu, Zhai, Huang, Jiang, Yu and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Wu, Kaijuan Zhai, Xingyu Huang, Shuaiqin Jiang, Liping Yu, Zheng Huang, Jing Protein Kinases: Potential Drug Targets Against Schistosoma japonicum |
title | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
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title_full | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
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title_fullStr | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
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title_full_unstemmed | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
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title_short | Protein Kinases: Potential Drug Targets Against Schistosoma japonicum
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title_sort | protein kinases: potential drug targets against schistosoma japonicum |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282181/ https://www.ncbi.nlm.nih.gov/pubmed/34277472 http://dx.doi.org/10.3389/fcimb.2021.691757 |
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