Tumor cells generate astrocyte-like cells that contribute to SHH-driven medulloblastoma relapse

Astrocytes, a major glial cell type in the brain, play a critical role in supporting the progression of medulloblastoma (MB), the most common malignant pediatric brain tumor. Through lineage tracing analyses and single-cell RNA sequencing, we demonstrate that astrocytes are predominantly derived fro...

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Detalles Bibliográficos
Autores principales: Guo, Duancheng, Wang, Yuan, Cheng, Yan, Liao, Shengyou, Hu, Jian, Du, Fang, Xu, Gang, Liu, Yongqiang, Cai, Kathy Q., Cheung, Martin, Wainwright, Brandon J., Lu, Q. Richard, Zhao, Yi, Yang, Zeng-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282281/
https://www.ncbi.nlm.nih.gov/pubmed/34254999
http://dx.doi.org/10.1084/jem.20202350

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