Putting the DOT on IL1A

IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence.

Detalles Bibliográficos
Autores principales: Olan, Ioana, Narita, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282306/
https://www.ncbi.nlm.nih.gov/pubmed/34254986
http://dx.doi.org/10.1083/jcb.202106164
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author Olan, Ioana
Narita, Masashi
author_facet Olan, Ioana
Narita, Masashi
author_sort Olan, Ioana
collection PubMed
description IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence.
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spelling pubmed-82823062022-02-02 Putting the DOT on IL1A Olan, Ioana Narita, Masashi J Cell Biol Spotlight IL-1α is an upstream component of the senescence-associated secretory phenotype. In this issue, Leon et al. (2021. J. Cell Biol. https://doi.org/10.1083/jcb.202008101) show that DOT1L-mediated H3K79 methylation at the IL1A gene plays a key role in its induction during oncogene-induced senescence. Rockefeller University Press 2021-07-13 /pmc/articles/PMC8282306/ /pubmed/34254986 http://dx.doi.org/10.1083/jcb.202106164 Text en © 2021 Olan and Narita http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Olan, Ioana
Narita, Masashi
Putting the DOT on IL1A
title Putting the DOT on IL1A
title_full Putting the DOT on IL1A
title_fullStr Putting the DOT on IL1A
title_full_unstemmed Putting the DOT on IL1A
title_short Putting the DOT on IL1A
title_sort putting the dot on il1a
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282306/
https://www.ncbi.nlm.nih.gov/pubmed/34254986
http://dx.doi.org/10.1083/jcb.202106164
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