Cargando…

A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

The causative agent of Chagas disease undergoes drastic morphological and biochemical modifications as it passes between hosts and transitions from extracellular to intracellular stages. The osmotic and mechanical aspects of these cellular transformations are not understood. Here we identify and cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dave, Noopur, Cetiner, Ugur, Arroyo, Daniel, Fonbuena, Joshua, Tiwari, Megna, Barrera, Patricia, Lander, Noelia, Anishkin, Andriy, Sukharev, Sergei, Jimenez, Veronica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282336/ https://www.ncbi.nlm.nih.gov/pubmed/34212856 http://dx.doi.org/10.7554/eLife.67449

Ejemplares similares

Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance
por: Anishkin, Andriy, et al.
Publicado: (2008)

Adaptive behavior of bacterial mechanosensitive channels is coupled to membrane mechanics
por: Belyy, Vladislav, et al.
Publicado: (2010)

The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding
por: Rowe, Ian, et al.
Publicado: (2014)

Mechanosensitive channel MscS is critical for termination of the bacterial hypoosmotic permeability response
por: Moller, Elissa, et al.
Publicado: (2023)

Dissipation during the Gating Cycle of the Bacterial Mechanosensitive Ion Channel Approaches the Landauer Limit
por: Çetiner, Uğur, et al.
Publicado: (2023)

Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes
por: Dumoulin, Peter C, et al.
Publicado: (2020)

Spontaneous dormancy protects Trypanosoma cruzi during extended drug exposure
por: Sánchez-Valdéz, Fernando J, et al.
Publicado: (2018)

Tension-activated channels in the mechanism of osmotic fitness in Pseudomonas aeruginosa
por: Çetiner, Uğur, et al.
Publicado: (2017)

On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL
por: Anishkin, Andriy, et al.
Publicado: (2003)

Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
por: Melo, Tatiana G, et al.
Publicado: (2019)

Cardiac Manifestations of Trypanosoma cruzi Infection in a Domestic Dog
por: Stoner, Caitlin H., et al.
Publicado: (2020)

The long and winding road of reverse genetics in Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2021)

Evidence of likely autochthonous Chagas disease in the southwestern United States: A case series of Trypanosoma cruzi seropositive blood donors
por: Lynn, Mary K., et al.
Publicado: (2022)

The “Dashpot” Mechanism of Stretch-dependent Gating in MscS
por: Akitake, Bradley, et al.
Publicado: (2005)

A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi
por: Barrera, Patricia, et al.
Publicado: (2020)

The core domain as the force sensor of the yeast mechanosensitive TRP channel
por: Su, Zhenwei, et al.
Publicado: (2011)

Corrigendum: A Novel Calcium-Activated Potassium Channel Controls Membrane Potential and Intracellular pH in Trypanosoma cruzi
por: Barrera, Patricia, et al.
Publicado: (2021)

Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL
por: Anishkin, Andriy, et al.
Publicado: (2005)

Unexpected plasticity in the life cycle of Trypanosoma brucei
por: Schuster, Sarah, et al.
Publicado: (2021)

Comment on ‘Unexpected plasticity in the life cycle of Trypanosoma brucei’
por: Matthews, Keith R, et al.
Publicado: (2022)

Tight hydrophobic core and flexible helices yield MscL with a high tension gating threshold and a membrane area mechanical strain buffer
por: Sharma, Arjun, et al.
Publicado: (2023)

Immunopathology and Trypanosoma congolense parasite sequestration cause acute cerebral trypanosomiasis
por: Silva Pereira, Sara, et al.
Publicado: (2022)

A CRISPR/Cas9-riboswitch-Based Method for Downregulation of Gene Expression in Trypanosoma cruzi
por: Lander, Noelia, et al.
Publicado: (2020)

The pathway and spatial scale for MscS inactivation
por: Kamaraju, Kishore, et al.
Publicado: (2011)

An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei
por: Cayla, Mathieu, et al.
Publicado: (2020)

A Rare Case of Tuberculosis as a Cause of Lytic Lesion of Talus Without Adjacent Bone Involvement in a Four-Year-Old Child
por: Sahoo, Samrat S, et al.
Publicado: (2021)

Do Low Hemoglobin Levels Affect the Healing Process of Periprosthetic Joint Infection?
por: Yaradılmış, Yüksel Uğur, et al.
Publicado: (2021)

Sequential Shifting in T-helper and T-cytotoxic Subset Cell Population in Mild and Severe COVID-19 Patients Infected With Variant B.1.61
por: Agarwal, Jyotsna, et al.
Publicado: (2023)

Flexible Bronchoscopy in a Patient With Pneumomediastinum and Hypoxemic Respiratory Failure: High-Flow Nasal Cannula to the Rescue
por: PB, Sryma, et al.
Publicado: (2021)

The voltage-dependence of MscL has dipolar and dielectric contributions and is governed by local intramembrane electric field
por: Najem, Joseph S., et al.
Publicado: (2018)

The Role of Sex in the Risk of Mortality From COVID-19 Amongst Adult Patients: A Systematic Review
por: Kelada, Monica, et al.
Publicado: (2020)

OXA-48 Dominance Meets Ceftazidime-Avibactam: A Battle Against Life-Threatening Carbapenem-Resistant Klebsiella pneumoniae Infections in the Intensive Care Unit
por: Önal, Uğur, et al.
Publicado: (2023)

Changes in the Management of Malignant Bone Tumors in the COVID-19 Pandemic in Developing Countries
por: Tiwari, Vivek, et al.
Publicado: (2022)

Distribution, frequency and clinical presentation of leptospirosis and coinfections: a systematic review protocol
por: Parra Barrera, Eliana L, et al.
Publicado: (2022)

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi
por: Chiurillo, Miguel A., et al.
Publicado: (2017)

Effect of porcine reproductive and respiratory syndrome virus 2 on angiogenesis and cell proliferation at the maternal-fetal interface
por: Barrera-Zarate, Javier A., et al.
Publicado: (2022)

Excretion of SARS-CoV-2 in breast milk: a single-centre observational study
por: Prasad, Arun, et al.
Publicado: (2021)

Retrospective cohort study of COVID-19 among children in Fulton County, Georgia, March 2020–June 2021
por: Barrera, Chloe M, et al.
Publicado: (2021)

Mitochondrial Pyruvate Carrier Subunits Are Essential for Pyruvate-Driven Respiration, Infectivity, and Intracellular Replication of Trypanosoma cruzi
por: Negreiros, Raquel S., et al.
Publicado: (2021)

Early Pandemic Evaluation and Enhanced Surveillance of COVID-19 (EAVE II): protocol for an observational study using linked Scottish national data
por: Simpson, Colin R, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qol7kdko8754ub31t08uahmktp