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Vestibulo-perceptual influences upon the vestibulo-spinal reflex

The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high-order neural phenomena can modulate short-late...

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Autores principales: Bonsu, Angela N., Nousi, Sofia, Lobo, Rhannon, Strutton, Paul H., Arshad, Qadeer, Bronstein, Adolfo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282553/
https://www.ncbi.nlm.nih.gov/pubmed/33969437
http://dx.doi.org/10.1007/s00221-021-06123-7
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author Bonsu, Angela N.
Nousi, Sofia
Lobo, Rhannon
Strutton, Paul H.
Arshad, Qadeer
Bronstein, Adolfo M.
author_facet Bonsu, Angela N.
Nousi, Sofia
Lobo, Rhannon
Strutton, Paul H.
Arshad, Qadeer
Bronstein, Adolfo M.
author_sort Bonsu, Angela N.
collection PubMed
description The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high-order neural phenomena can modulate short-latency vestibulo-spinal responses. Here, we investigate this by assessing click-evoked cervical vestibular myogenic-evoked potentials (VEMPS) during visual roll motion that elicited an illusionary sensation of self-motion (i.e. vection). We observed that during vection, the amplitude of the VEMPs was enhanced when compared to baseline measures. This modulation in VEMP amplitude was positively correlated with the subjective reports of vection strength. That is, those subjects reporting greater subjective vection scores exhibited a greater increase in VEMP amplitude. Control experiments showed that simple arousal (cold-induced discomfort) also increased VEMP amplitude but that, unlike vection, it did not modulate VEMP amplitude linearly. In agreement, small-field visual roll motion that did not induce vection failed to increase VEMP amplitude. Taken together, our results demonstrate that vection can modify the response of vestibulo-collic reflexes. Even short-latency brainstem vestibulo-spinal reflexes are influenced by high-order mechanisms, illustrating the functional importance of perceptual mechanisms in human postural control. As VEMPs are inhibitory responses, we argue that the findings may represent a mechanism whereby high-order CNS mechanisms reduce activity levels in vestibulo-collic reflexes, necessary for instance when voluntary head movements need to be performed.
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spelling pubmed-82825532021-07-20 Vestibulo-perceptual influences upon the vestibulo-spinal reflex Bonsu, Angela N. Nousi, Sofia Lobo, Rhannon Strutton, Paul H. Arshad, Qadeer Bronstein, Adolfo M. Exp Brain Res Research Article The vestibular system facilitates gaze and postural stability via the vestibulo-ocular (VOR) and vestibulo-spinal reflexes, respectively. Cortical and perceptual mechanisms can modulate long-duration VOR responses, but little is known about whether high-order neural phenomena can modulate short-latency vestibulo-spinal responses. Here, we investigate this by assessing click-evoked cervical vestibular myogenic-evoked potentials (VEMPS) during visual roll motion that elicited an illusionary sensation of self-motion (i.e. vection). We observed that during vection, the amplitude of the VEMPs was enhanced when compared to baseline measures. This modulation in VEMP amplitude was positively correlated with the subjective reports of vection strength. That is, those subjects reporting greater subjective vection scores exhibited a greater increase in VEMP amplitude. Control experiments showed that simple arousal (cold-induced discomfort) also increased VEMP amplitude but that, unlike vection, it did not modulate VEMP amplitude linearly. In agreement, small-field visual roll motion that did not induce vection failed to increase VEMP amplitude. Taken together, our results demonstrate that vection can modify the response of vestibulo-collic reflexes. Even short-latency brainstem vestibulo-spinal reflexes are influenced by high-order mechanisms, illustrating the functional importance of perceptual mechanisms in human postural control. As VEMPs are inhibitory responses, we argue that the findings may represent a mechanism whereby high-order CNS mechanisms reduce activity levels in vestibulo-collic reflexes, necessary for instance when voluntary head movements need to be performed. Springer Berlin Heidelberg 2021-05-09 2021 /pmc/articles/PMC8282553/ /pubmed/33969437 http://dx.doi.org/10.1007/s00221-021-06123-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Bonsu, Angela N.
Nousi, Sofia
Lobo, Rhannon
Strutton, Paul H.
Arshad, Qadeer
Bronstein, Adolfo M.
Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title_full Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title_fullStr Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title_full_unstemmed Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title_short Vestibulo-perceptual influences upon the vestibulo-spinal reflex
title_sort vestibulo-perceptual influences upon the vestibulo-spinal reflex
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282553/
https://www.ncbi.nlm.nih.gov/pubmed/33969437
http://dx.doi.org/10.1007/s00221-021-06123-7
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