Serotonin: a platelet hormone modulating cardiovascular disease

Cardiovascular diseases and depression are significant health burdens and increasing evidence suggests a causal relationship between them. The incidence of depression among patients suffering from cardiovascular disease is markedly elevated, and depression itself is an established cardiovascular ris...

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Autores principales: Rieder, Marina, Gauchel, Nadine, Bode, Christoph, Duerschmied, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282555/
https://www.ncbi.nlm.nih.gov/pubmed/33155668
http://dx.doi.org/10.1007/s11239-020-02331-0
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author Rieder, Marina
Gauchel, Nadine
Bode, Christoph
Duerschmied, Daniel
author_facet Rieder, Marina
Gauchel, Nadine
Bode, Christoph
Duerschmied, Daniel
author_sort Rieder, Marina
collection PubMed
description Cardiovascular diseases and depression are significant health burdens and increasing evidence suggests a causal relationship between them. The incidence of depression among patients suffering from cardiovascular disease is markedly elevated, and depression itself is an established cardiovascular risk factor. Serotonin 5-hydroxytryptamin (5-HT), a biogenic amine acting as a neurotransmitter and a peripheral hormone, is involved in the pathogenesis of both, cardiovascular disease and depression. Novel cardiovascular functions of 5-HT have recently been described and will be summarized in this review. 5-HT has a broad spectrum of functions in the cardiovascular system, yet the clinical or experimental data are partly conflicting. There is further research needed to characterize the clinical effects of 5-HT in particular tissues to enable targeted pharmacological therapies.
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spelling pubmed-82825552021-07-20 Serotonin: a platelet hormone modulating cardiovascular disease Rieder, Marina Gauchel, Nadine Bode, Christoph Duerschmied, Daniel J Thromb Thrombolysis Article Cardiovascular diseases and depression are significant health burdens and increasing evidence suggests a causal relationship between them. The incidence of depression among patients suffering from cardiovascular disease is markedly elevated, and depression itself is an established cardiovascular risk factor. Serotonin 5-hydroxytryptamin (5-HT), a biogenic amine acting as a neurotransmitter and a peripheral hormone, is involved in the pathogenesis of both, cardiovascular disease and depression. Novel cardiovascular functions of 5-HT have recently been described and will be summarized in this review. 5-HT has a broad spectrum of functions in the cardiovascular system, yet the clinical or experimental data are partly conflicting. There is further research needed to characterize the clinical effects of 5-HT in particular tissues to enable targeted pharmacological therapies. Springer US 2020-11-05 2021 /pmc/articles/PMC8282555/ /pubmed/33155668 http://dx.doi.org/10.1007/s11239-020-02331-0 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Rieder, Marina
Gauchel, Nadine
Bode, Christoph
Duerschmied, Daniel
Serotonin: a platelet hormone modulating cardiovascular disease
title Serotonin: a platelet hormone modulating cardiovascular disease
title_full Serotonin: a platelet hormone modulating cardiovascular disease
title_fullStr Serotonin: a platelet hormone modulating cardiovascular disease
title_full_unstemmed Serotonin: a platelet hormone modulating cardiovascular disease
title_short Serotonin: a platelet hormone modulating cardiovascular disease
title_sort serotonin: a platelet hormone modulating cardiovascular disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282555/
https://www.ncbi.nlm.nih.gov/pubmed/33155668
http://dx.doi.org/10.1007/s11239-020-02331-0
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AT duerschmieddaniel serotoninaplatelethormonemodulatingcardiovasculardisease

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