Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was id...

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Autores principales: Francis, Magen E., Richardson, Brian, Goncin, Una, McNeil, Mara, Rioux, Melissa, Foley, Mary K., Ge, Anni, Pechous, Roger D., Kindrachuk, Jason, Cameron, Cheryl M., Richardson, Christopher, Lew, Jocelyne, Machtaler, Steven, Cameron, Mark J., Gerdts, Volker, Falzarano, Darryl, Kelvin, Alyson A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282673/
https://www.ncbi.nlm.nih.gov/pubmed/34267262
http://dx.doi.org/10.1038/s41598-021-93855-9
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author Francis, Magen E.
Richardson, Brian
Goncin, Una
McNeil, Mara
Rioux, Melissa
Foley, Mary K.
Ge, Anni
Pechous, Roger D.
Kindrachuk, Jason
Cameron, Cheryl M.
Richardson, Christopher
Lew, Jocelyne
Machtaler, Steven
Cameron, Mark J.
Gerdts, Volker
Falzarano, Darryl
Kelvin, Alyson A.
author_facet Francis, Magen E.
Richardson, Brian
Goncin, Una
McNeil, Mara
Rioux, Melissa
Foley, Mary K.
Ge, Anni
Pechous, Roger D.
Kindrachuk, Jason
Cameron, Cheryl M.
Richardson, Christopher
Lew, Jocelyne
Machtaler, Steven
Cameron, Mark J.
Gerdts, Volker
Falzarano, Darryl
Kelvin, Alyson A.
author_sort Francis, Magen E.
collection PubMed
description SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.
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spelling pubmed-82826732021-07-19 Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets Francis, Magen E. Richardson, Brian Goncin, Una McNeil, Mara Rioux, Melissa Foley, Mary K. Ge, Anni Pechous, Roger D. Kindrachuk, Jason Cameron, Cheryl M. Richardson, Christopher Lew, Jocelyne Machtaler, Steven Cameron, Mark J. Gerdts, Volker Falzarano, Darryl Kelvin, Alyson A. Sci Rep Article SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses. Nature Publishing Group UK 2021-07-15 /pmc/articles/PMC8282673/ /pubmed/34267262 http://dx.doi.org/10.1038/s41598-021-93855-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Francis, Magen E.
Richardson, Brian
Goncin, Una
McNeil, Mara
Rioux, Melissa
Foley, Mary K.
Ge, Anni
Pechous, Roger D.
Kindrachuk, Jason
Cameron, Cheryl M.
Richardson, Christopher
Lew, Jocelyne
Machtaler, Steven
Cameron, Mark J.
Gerdts, Volker
Falzarano, Darryl
Kelvin, Alyson A.
Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_full Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_fullStr Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_full_unstemmed Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_short Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets
title_sort sex and age bias viral burden and interferon responses during sars-cov-2 infection in ferrets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282673/
https://www.ncbi.nlm.nih.gov/pubmed/34267262
http://dx.doi.org/10.1038/s41598-021-93855-9
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