PGE2-JNK signaling axis non-canonically promotes Gli activation by protecting Gli2 from ubiquitin-proteasomal degradation

Both bench and bedside investigations have challenged the supportive role of Hedgehog (Hh) activity in the progression of colorectal cancers, thus raising a critical need to further deeply determine the contribution of Hh to the growth of colorectal cancer. Combining multiple complementary means, in...

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Detalles Bibliográficos
Autores principales: Yang, Jun, Wang, Juan, Liu, Yuan, Zhang, Yu, Huang, Wenjing, Zou, Yu, Qiu, Yanyan, Cai, Weiyang, Gao, Jing, Zhou, Hu, Wu, Yingli, Liu, Weijun, Ding, Qingqing, Zhang, Yanjie, Yin, Pei-hao, Tan, Wenfu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282835/
https://www.ncbi.nlm.nih.gov/pubmed/34267186
http://dx.doi.org/10.1038/s41419-021-03995-z

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