Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis

AIMS: This meta-analysis aims to analyze the association of calcium channel blocker (CCB) use with COVID-19 clinical outcomes. METHODS: PubMed, ProQuest, Science Direct, Scopus, and medRxiv databases were searched systematically in a limited period. The primary outcome was mortality. RESULTS: A tota...

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Autores principales: Alsagaff, Mochamad Yusuf, Mulia, Eka Prasetya Budi, Maghfirah, Irma, Luke, Kevin, Nugraha, David, Rachmi, Dita Aulia, Septianda, Imanita, A'yun, Maya Qurota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Diabetes India. Published by Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282943/
https://www.ncbi.nlm.nih.gov/pubmed/34298269
http://dx.doi.org/10.1016/j.dsx.2021.102210
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author Alsagaff, Mochamad Yusuf
Mulia, Eka Prasetya Budi
Maghfirah, Irma
Luke, Kevin
Nugraha, David
Rachmi, Dita Aulia
Septianda, Imanita
A'yun, Maya Qurota
author_facet Alsagaff, Mochamad Yusuf
Mulia, Eka Prasetya Budi
Maghfirah, Irma
Luke, Kevin
Nugraha, David
Rachmi, Dita Aulia
Septianda, Imanita
A'yun, Maya Qurota
author_sort Alsagaff, Mochamad Yusuf
collection PubMed
description AIMS: This meta-analysis aims to analyze the association of calcium channel blocker (CCB) use with COVID-19 clinical outcomes. METHODS: PubMed, ProQuest, Science Direct, Scopus, and medRxiv databases were searched systematically in a limited period. The primary outcome was mortality. RESULTS: A total of 119,298 patients from 31 eligible studies were included. Pooled analysis of the random-effect model revealed CCB was not associated with reduced mortality (OR = 1.21 [95%CI: 0.98–1.49], p = 0.08). Interestingly, subgroup analysis in hypertensive patients revealed significantly reduced mortality (OR = 0.69 [95%CI: 0.52–0.91], p = 0.009). CONCLUSION: CCB usage was not associated with the outcome of COVID-19. However, CCB was associated with a decreased mortality rate in hypertensive COVID-19 patients.
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spelling pubmed-82829432021-07-20 Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis Alsagaff, Mochamad Yusuf Mulia, Eka Prasetya Budi Maghfirah, Irma Luke, Kevin Nugraha, David Rachmi, Dita Aulia Septianda, Imanita A'yun, Maya Qurota Diabetes Metab Syndr Review AIMS: This meta-analysis aims to analyze the association of calcium channel blocker (CCB) use with COVID-19 clinical outcomes. METHODS: PubMed, ProQuest, Science Direct, Scopus, and medRxiv databases were searched systematically in a limited period. The primary outcome was mortality. RESULTS: A total of 119,298 patients from 31 eligible studies were included. Pooled analysis of the random-effect model revealed CCB was not associated with reduced mortality (OR = 1.21 [95%CI: 0.98–1.49], p = 0.08). Interestingly, subgroup analysis in hypertensive patients revealed significantly reduced mortality (OR = 0.69 [95%CI: 0.52–0.91], p = 0.009). CONCLUSION: CCB usage was not associated with the outcome of COVID-19. However, CCB was associated with a decreased mortality rate in hypertensive COVID-19 patients. Diabetes India. Published by Elsevier Ltd. 2021 2021-07-16 /pmc/articles/PMC8282943/ /pubmed/34298269 http://dx.doi.org/10.1016/j.dsx.2021.102210 Text en © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Alsagaff, Mochamad Yusuf
Mulia, Eka Prasetya Budi
Maghfirah, Irma
Luke, Kevin
Nugraha, David
Rachmi, Dita Aulia
Septianda, Imanita
A'yun, Maya Qurota
Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title_full Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title_fullStr Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title_full_unstemmed Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title_short Association of calcium channel blocker use with clinical outcome of COVID-19: A meta-analysis
title_sort association of calcium channel blocker use with clinical outcome of covid-19: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282943/
https://www.ncbi.nlm.nih.gov/pubmed/34298269
http://dx.doi.org/10.1016/j.dsx.2021.102210
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