Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis

The standard of care for treatment of sino-orbital mucormycosis involves aggressive surgical debridement and liposomal amphotericin, and the roles of adjunctive and topical therapies are less clear. Here we describe a case of severe refractory sino-orbital mucormycosis in an immunocompetent patient...

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Autores principales: Beaver, Ryan, Garza, Brianna, Vallabhaneni, Hasanthi, Cahuayme-Zuniga, Lizbeth, Midturi, John, LaDow, Tiffany
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282967/
https://www.ncbi.nlm.nih.gov/pubmed/34295641
http://dx.doi.org/10.1016/j.mmcr.2021.06.003
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author Beaver, Ryan
Garza, Brianna
Vallabhaneni, Hasanthi
Cahuayme-Zuniga, Lizbeth
Midturi, John
LaDow, Tiffany
author_facet Beaver, Ryan
Garza, Brianna
Vallabhaneni, Hasanthi
Cahuayme-Zuniga, Lizbeth
Midturi, John
LaDow, Tiffany
author_sort Beaver, Ryan
collection PubMed
description The standard of care for treatment of sino-orbital mucormycosis involves aggressive surgical debridement and liposomal amphotericin, and the roles of adjunctive and topical therapies are less clear. Here we describe a case of severe refractory sino-orbital mucormycosis in an immunocompetent patient who responded to combination therapy with liposomal amphotericin, isavuconazole, micafungin, and topical amphotericin deoxycholate after failing to achieve negative surgical margins.
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spelling pubmed-82829672021-07-21 Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis Beaver, Ryan Garza, Brianna Vallabhaneni, Hasanthi Cahuayme-Zuniga, Lizbeth Midturi, John LaDow, Tiffany Med Mycol Case Rep Case Report The standard of care for treatment of sino-orbital mucormycosis involves aggressive surgical debridement and liposomal amphotericin, and the roles of adjunctive and topical therapies are less clear. Here we describe a case of severe refractory sino-orbital mucormycosis in an immunocompetent patient who responded to combination therapy with liposomal amphotericin, isavuconazole, micafungin, and topical amphotericin deoxycholate after failing to achieve negative surgical margins. Elsevier 2021-07-05 /pmc/articles/PMC8282967/ /pubmed/34295641 http://dx.doi.org/10.1016/j.mmcr.2021.06.003 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Beaver, Ryan
Garza, Brianna
Vallabhaneni, Hasanthi
Cahuayme-Zuniga, Lizbeth
Midturi, John
LaDow, Tiffany
Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title_full Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title_fullStr Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title_full_unstemmed Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title_short Use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
title_sort use of topical amphotericin in a case of refractory sino-orbital angioinvasive mucormycosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282967/
https://www.ncbi.nlm.nih.gov/pubmed/34295641
http://dx.doi.org/10.1016/j.mmcr.2021.06.003
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