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Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES)
To investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283037/ https://www.ncbi.nlm.nih.gov/pubmed/34307002 http://dx.doi.org/10.1016/j.pmedr.2021.101485 |
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author | Llamas-Velasco, Sara Contador, Israel Méndez-Guerrero, Antonio Romero Ferreiro, Carmen Benito-León, Julián Villarejo-Galende, Alberto Bermejo-Pareja, Félix |
author_facet | Llamas-Velasco, Sara Contador, Israel Méndez-Guerrero, Antonio Romero Ferreiro, Carmen Benito-León, Julián Villarejo-Galende, Alberto Bermejo-Pareja, Félix |
author_sort | Llamas-Velasco, Sara |
collection | PubMed |
description | To investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based cohort survey of older subjects (≥65 years) that comprised 5278 census-based participants at baseline (1994–1995). A modified version of Rosow-Breslau questionnaire was applied to categorize PA into active versus sedentary group. The final diagnosis of PD and parkinsonism was made by an expert neurologist. Cox regression models (CRM) adjusted for several covariates (sex, age, education, alcohol consumption, tobacco, stroke, hypertension and body mass index) were used to calculate the association between PA (active group vs. sedentary) and risk of PD and parkinsonism after three years. 22 incident PD and 25 incident parkinsonism cases were identified among 2943 participants with available PA information (57.1% female; mean age = 73.28 ± 6.24 years) after three years of follow-up. The CRM showed that the active group (vs. sedentary) showed a lower risk of parkinsonism (Hazard ratio (HR) = 0.18; 95% CI [0.07–0.51]; p = 0.0001). However, this effect was restricted to men (HR = 0.34; 95% CI [0.11–0.99], p < 0.05) for incident PD. PA may be a protective factor for incident parkinsonism, whereas this effect was only significant for men in the case of PD. The mechanisms implicated for brain maintenance in active individuals and the neurophysiological differences behind the role of sex on PD are discussed. |
format | Online Article Text |
id | pubmed-8283037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
record_format | MEDLINE/PubMed |
spelling | pubmed-82830372021-07-22 Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) Llamas-Velasco, Sara Contador, Israel Méndez-Guerrero, Antonio Romero Ferreiro, Carmen Benito-León, Julián Villarejo-Galende, Alberto Bermejo-Pareja, Félix Prev Med Rep Regular Article To investigate whether physical activity (PA) is a protective factor for the incidence of Parkinson’s disease (PD) and parkinsonism after three years of follow-up. All participants of this study were obtained from the Neurological Disorders in Central Spain (NEDICES), a prospective population-based cohort survey of older subjects (≥65 years) that comprised 5278 census-based participants at baseline (1994–1995). A modified version of Rosow-Breslau questionnaire was applied to categorize PA into active versus sedentary group. The final diagnosis of PD and parkinsonism was made by an expert neurologist. Cox regression models (CRM) adjusted for several covariates (sex, age, education, alcohol consumption, tobacco, stroke, hypertension and body mass index) were used to calculate the association between PA (active group vs. sedentary) and risk of PD and parkinsonism after three years. 22 incident PD and 25 incident parkinsonism cases were identified among 2943 participants with available PA information (57.1% female; mean age = 73.28 ± 6.24 years) after three years of follow-up. The CRM showed that the active group (vs. sedentary) showed a lower risk of parkinsonism (Hazard ratio (HR) = 0.18; 95% CI [0.07–0.51]; p = 0.0001). However, this effect was restricted to men (HR = 0.34; 95% CI [0.11–0.99], p < 0.05) for incident PD. PA may be a protective factor for incident parkinsonism, whereas this effect was only significant for men in the case of PD. The mechanisms implicated for brain maintenance in active individuals and the neurophysiological differences behind the role of sex on PD are discussed. 2021-07-08 /pmc/articles/PMC8283037/ /pubmed/34307002 http://dx.doi.org/10.1016/j.pmedr.2021.101485 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Llamas-Velasco, Sara Contador, Israel Méndez-Guerrero, Antonio Romero Ferreiro, Carmen Benito-León, Julián Villarejo-Galende, Alberto Bermejo-Pareja, Félix Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title | Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title_full | Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title_fullStr | Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title_full_unstemmed | Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title_short | Physical activity and risk of Parkinson’s disease and parkinsonism in a prospective population-based study (NEDICES) |
title_sort | physical activity and risk of parkinson’s disease and parkinsonism in a prospective population-based study (nedices) |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283037/ https://www.ncbi.nlm.nih.gov/pubmed/34307002 http://dx.doi.org/10.1016/j.pmedr.2021.101485 |
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