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PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES

BACKGROUND: Patellofemoral joint cartilage defects are difficult to treat due to their unique thickness and topography. Numerous cartilage restoration techniques are available to surgeons treating articular cartilage defects. However, patellofemoral joint restoration historically produces worse outc...

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Autores principales: Dawkins, Brody J., Stein, Beth E. Shubin, Mintz, Douglas N., Fabricant, Peter D., Gomoll, Andreas H., Strickland, Sabrina M., Aitchison, Alexandra H., Green, Daniel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283086/
http://dx.doi.org/10.1177/2325967121S00136
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author Dawkins, Brody J.
Stein, Beth E. Shubin
Mintz, Douglas N.
Fabricant, Peter D.
Gomoll, Andreas H.
Strickland, Sabrina M.
Aitchison, Alexandra H.
Green, Daniel W.
author_facet Dawkins, Brody J.
Stein, Beth E. Shubin
Mintz, Douglas N.
Fabricant, Peter D.
Gomoll, Andreas H.
Strickland, Sabrina M.
Aitchison, Alexandra H.
Green, Daniel W.
author_sort Dawkins, Brody J.
collection PubMed
description BACKGROUND: Patellofemoral joint cartilage defects are difficult to treat due to their unique thickness and topography. Numerous cartilage restoration techniques are available to surgeons treating articular cartilage defects. However, patellofemoral joint restoration historically produces worse outcomes than tibiofemoral joint restoration. One cell-based option is particulated juvenile allograft cartilage (PJAC), though literature regarding the efficacy of this treatment is sparse, especially in patients under the age of 21 years. HYPOTHESIS/ PURPOSE: The aim of this study is to investigate postoperative outcomes of PJAC for patellofemoral chondral defects using MRI and return to sport rates in this active, high-demand patient population. METHODS: Patients at an urban tertiary care musculoskeletal institution who underwent PJAC for patellofemoral joint cartilage restoration were identified through records review. Patients 21 years old or younger with minimum clinical follow-up of 1 year and postoperative MRI at a minimum of 6 months after surgery were included. Cartilage restoration was assessed by MRI using the International Cartilage Repair Society’s standardized system. Sport activity was collected from medical records. RESULTS: Thirty-six knees in 34 patients with a mean age of 16.1 ± 3.1 years old (range 10—21 years old) were analyzed. Mean follow-up was 32.1 months. Defects were located on the patella in 25 knees, and trochlea in 11 knees (Figure 1). There were no bipolar lesions in the cohort. Mean defect size was 2.47 cm(2). Twenty-four knees (66.7%) were graded either ‘normal’ or ‘nearly normal’, and 28 knees (77.8%) had greater than 50% of the defect filled on follow-up imaging. Return to sport rates among patients who participated in a sport preoperatively was 100%. CONCLUSION: Restoration of patellofemoral chondral defects in young patients with particulated juvenile allograft can be performed with satisfactory short-term efficacy, excellent postoperative MRI appearance, and very high rates of return to sport. TABLES/FIGURES:
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spelling pubmed-82830862021-08-02 PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES Dawkins, Brody J. Stein, Beth E. Shubin Mintz, Douglas N. Fabricant, Peter D. Gomoll, Andreas H. Strickland, Sabrina M. Aitchison, Alexandra H. Green, Daniel W. Orthop J Sports Med Article BACKGROUND: Patellofemoral joint cartilage defects are difficult to treat due to their unique thickness and topography. Numerous cartilage restoration techniques are available to surgeons treating articular cartilage defects. However, patellofemoral joint restoration historically produces worse outcomes than tibiofemoral joint restoration. One cell-based option is particulated juvenile allograft cartilage (PJAC), though literature regarding the efficacy of this treatment is sparse, especially in patients under the age of 21 years. HYPOTHESIS/ PURPOSE: The aim of this study is to investigate postoperative outcomes of PJAC for patellofemoral chondral defects using MRI and return to sport rates in this active, high-demand patient population. METHODS: Patients at an urban tertiary care musculoskeletal institution who underwent PJAC for patellofemoral joint cartilage restoration were identified through records review. Patients 21 years old or younger with minimum clinical follow-up of 1 year and postoperative MRI at a minimum of 6 months after surgery were included. Cartilage restoration was assessed by MRI using the International Cartilage Repair Society’s standardized system. Sport activity was collected from medical records. RESULTS: Thirty-six knees in 34 patients with a mean age of 16.1 ± 3.1 years old (range 10—21 years old) were analyzed. Mean follow-up was 32.1 months. Defects were located on the patella in 25 knees, and trochlea in 11 knees (Figure 1). There were no bipolar lesions in the cohort. Mean defect size was 2.47 cm(2). Twenty-four knees (66.7%) were graded either ‘normal’ or ‘nearly normal’, and 28 knees (77.8%) had greater than 50% of the defect filled on follow-up imaging. Return to sport rates among patients who participated in a sport preoperatively was 100%. CONCLUSION: Restoration of patellofemoral chondral defects in young patients with particulated juvenile allograft can be performed with satisfactory short-term efficacy, excellent postoperative MRI appearance, and very high rates of return to sport. TABLES/FIGURES: SAGE Publications 2021-07-14 /pmc/articles/PMC8283086/ http://dx.doi.org/10.1177/2325967121S00136 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc-nd/4.0/This open-access article is published and distributed under the Creative Commons Attribution - NonCommercial - No Derivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits the noncommercial use, distribution, and reproduction of the article in any medium, provided the original author and source are credited. You may not alter, transform, or build upon this article without the permission of the Author(s). For article reuse guidelines, please visit SAGE’s website at http://www.sagepub.com/journals-permissions.
spellingShingle Article
Dawkins, Brody J.
Stein, Beth E. Shubin
Mintz, Douglas N.
Fabricant, Peter D.
Gomoll, Andreas H.
Strickland, Sabrina M.
Aitchison, Alexandra H.
Green, Daniel W.
PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title_full PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title_fullStr PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title_full_unstemmed PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title_short PATELLOFEMORAL JOINT CARTILAGE RESTORATION WITH PARTICULATED JUVENILE ALLOGRAFT IN PATIENTS UNDER 21 YEARS OLD: POSTOPERATIVE MRI ANALYSIS AND RETURN TO SPORT RATES
title_sort patellofemoral joint cartilage restoration with particulated juvenile allograft in patients under 21 years old: postoperative mri analysis and return to sport rates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283086/
http://dx.doi.org/10.1177/2325967121S00136
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