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Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment
CASE SUMMARY: A 7-year-old spayed female domestic shorthair cat weighing 5 kg was referred with polyuria, polydipsia, lethargy, abdominal distension and dermatologic abnormalities. Diabetes mellitus was diagnosed and treatment was started with a diet for diabetic cats and insulin glargine (1 IU q12h...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283091/ https://www.ncbi.nlm.nih.gov/pubmed/34345435 http://dx.doi.org/10.1177/20551169211029896 |
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author | Miceli, Diego D Zelarayán, Gabriela S García, Jorge D Fernández, Viviana Ferraris, Sergio |
author_facet | Miceli, Diego D Zelarayán, Gabriela S García, Jorge D Fernández, Viviana Ferraris, Sergio |
author_sort | Miceli, Diego D |
collection | PubMed |
description | CASE SUMMARY: A 7-year-old spayed female domestic shorthair cat weighing 5 kg was referred with polyuria, polydipsia, lethargy, abdominal distension and dermatologic abnormalities. Diabetes mellitus was diagnosed and treatment was started with a diet for diabetic cats and insulin glargine (1 IU q12h SC). Hyperadrenocorticism (HAC) was suspected and diagnosed based on clinical signs, increased urinary cortisol:creatinine ratio, lack of suppression on low-dose dexamethasone suppression test and abdominal ultrasonography demonstrating bilateral adrenal enlargement. Oral cabergoline (10 μg/kg every other day) was initiated. After the second administration of cabergoline, the cat suffered from clinical hypoglycemia and no longer required insulin. One month after insulin withdrawal, blood work and urine analysis results showed normoglycemia, a normal serum fructosamine concentration (244 μmol/l) and normal urine analysis without glycosuria. Diabetic remission persisted until its death 7 months later. In addition, cabergoline treatment was associated with improvement in clinical signs such as lethargy, seborrhea, alopecia and abdominal distension. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first reported case of the use of cabergoline in a cat with HAC, as well as the first reported case of diabetic remission in a cat with HAC after cabergoline treatment. Cabergoline could be an alternative treatment for diabetic cats with pituitary-dependent HAC. Further work should focus on different protocols with greater number of cases. |
format | Online Article Text |
id | pubmed-8283091 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82830912021-08-02 Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment Miceli, Diego D Zelarayán, Gabriela S García, Jorge D Fernández, Viviana Ferraris, Sergio JFMS Open Rep Case Report CASE SUMMARY: A 7-year-old spayed female domestic shorthair cat weighing 5 kg was referred with polyuria, polydipsia, lethargy, abdominal distension and dermatologic abnormalities. Diabetes mellitus was diagnosed and treatment was started with a diet for diabetic cats and insulin glargine (1 IU q12h SC). Hyperadrenocorticism (HAC) was suspected and diagnosed based on clinical signs, increased urinary cortisol:creatinine ratio, lack of suppression on low-dose dexamethasone suppression test and abdominal ultrasonography demonstrating bilateral adrenal enlargement. Oral cabergoline (10 μg/kg every other day) was initiated. After the second administration of cabergoline, the cat suffered from clinical hypoglycemia and no longer required insulin. One month after insulin withdrawal, blood work and urine analysis results showed normoglycemia, a normal serum fructosamine concentration (244 μmol/l) and normal urine analysis without glycosuria. Diabetic remission persisted until its death 7 months later. In addition, cabergoline treatment was associated with improvement in clinical signs such as lethargy, seborrhea, alopecia and abdominal distension. RELEVANCE AND NOVEL INFORMATION: To our knowledge, this is the first reported case of the use of cabergoline in a cat with HAC, as well as the first reported case of diabetic remission in a cat with HAC after cabergoline treatment. Cabergoline could be an alternative treatment for diabetic cats with pituitary-dependent HAC. Further work should focus on different protocols with greater number of cases. SAGE Publications 2021-07-13 /pmc/articles/PMC8283091/ /pubmed/34345435 http://dx.doi.org/10.1177/20551169211029896 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Miceli, Diego D Zelarayán, Gabriela S García, Jorge D Fernández, Viviana Ferraris, Sergio Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title | Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title_full | Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title_fullStr | Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title_full_unstemmed | Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title_short | Diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
title_sort | diabetes mellitus remission in a cat with hyperadrenocorticism after cabergoline treatment |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283091/ https://www.ncbi.nlm.nih.gov/pubmed/34345435 http://dx.doi.org/10.1177/20551169211029896 |
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