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Partial mGlu(5) Negative Allosteric Modulator M-5MPEP Demonstrates Antidepressant-Like Effects on Sleep Without Affecting Cognition or Quantitative EEG

Selective negative allosteric modulators (NAMs) targeting the metabotropic glutamate receptor subtype 5 (mGlu(5)) demonstrate anxiolytic-like and antidepressant-like effects yet concern regarding adverse effect liability remains. Functional coupling of mGlu(5) with ionotropic N-methyl-D-aspartate re...

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Detalles Bibliográficos
Autores principales:	Holter, Kimberly M., Lekander, Alex D., LaValley, Christina M., Bedingham, Elizabeth G., Pierce, Bethany E., Sands, L. Paul, Lindsley, Craig W., Jones, Carrie K., Gould, Robert W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283128/ https://www.ncbi.nlm.nih.gov/pubmed/34276300 http://dx.doi.org/10.3389/fnins.2021.700822

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