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Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study

Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [(11)C]UCB‐J PET to quantify synaptic density in comparison with 19 healthy controls and one symptomatic patient w...

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Autores principales: Malpetti, Maura, Holland, Negin, Jones, P. Simon, Ye, Rong, Cope, Thomas E., Fryer, Tim D., Hong, Young T., Savulich, George, Rittman, Timothy, Passamonti, Luca, Mak, Elijah, Aigbirhio, Franklin I., O’Brien, John T., Rowe, James B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283163/
https://www.ncbi.nlm.nih.gov/pubmed/34133849
http://dx.doi.org/10.1002/acn3.51407
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author Malpetti, Maura
Holland, Negin
Jones, P. Simon
Ye, Rong
Cope, Thomas E.
Fryer, Tim D.
Hong, Young T.
Savulich, George
Rittman, Timothy
Passamonti, Luca
Mak, Elijah
Aigbirhio, Franklin I.
O’Brien, John T.
Rowe, James B.
author_facet Malpetti, Maura
Holland, Negin
Jones, P. Simon
Ye, Rong
Cope, Thomas E.
Fryer, Tim D.
Hong, Young T.
Savulich, George
Rittman, Timothy
Passamonti, Luca
Mak, Elijah
Aigbirhio, Franklin I.
O’Brien, John T.
Rowe, James B.
author_sort Malpetti, Maura
collection PubMed
description Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [(11)C]UCB‐J PET to quantify synaptic density in comparison with 19 healthy controls and one symptomatic patient with behavioural variant frontotemporal dementia. The three pre‐symptomatic C9orf72 carriers showed reduced synaptic density in the thalamus compared to controls, and there was an additional extensive synaptic loss in frontotemporal regions of the symptomatic patient. [(11)C]UCB‐J PET may facilitate early, pre‐symptomatic assessment, monitoring of disease progression and evaluation of new preventive treatment strategies for frontotemporal dementia.
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spelling pubmed-82831632021-07-21 Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study Malpetti, Maura Holland, Negin Jones, P. Simon Ye, Rong Cope, Thomas E. Fryer, Tim D. Hong, Young T. Savulich, George Rittman, Timothy Passamonti, Luca Mak, Elijah Aigbirhio, Franklin I. O’Brien, John T. Rowe, James B. Ann Clin Transl Neurol Brief Communications Synaptic loss is an early and clinically relevant feature of many neurodegenerative diseases. Here we assess three adults at risk of frontotemporal dementia from C9orf72 mutation, using [(11)C]UCB‐J PET to quantify synaptic density in comparison with 19 healthy controls and one symptomatic patient with behavioural variant frontotemporal dementia. The three pre‐symptomatic C9orf72 carriers showed reduced synaptic density in the thalamus compared to controls, and there was an additional extensive synaptic loss in frontotemporal regions of the symptomatic patient. [(11)C]UCB‐J PET may facilitate early, pre‐symptomatic assessment, monitoring of disease progression and evaluation of new preventive treatment strategies for frontotemporal dementia. John Wiley and Sons Inc. 2021-06-16 /pmc/articles/PMC8283163/ /pubmed/34133849 http://dx.doi.org/10.1002/acn3.51407 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Malpetti, Maura
Holland, Negin
Jones, P. Simon
Ye, Rong
Cope, Thomas E.
Fryer, Tim D.
Hong, Young T.
Savulich, George
Rittman, Timothy
Passamonti, Luca
Mak, Elijah
Aigbirhio, Franklin I.
O’Brien, John T.
Rowe, James B.
Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title_full Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title_fullStr Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title_full_unstemmed Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title_short Synaptic density in carriers of C9orf72 mutations: a [(11)C]UCB‐J PET study
title_sort synaptic density in carriers of c9orf72 mutations: a [(11)c]ucb‐j pet study
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283163/
https://www.ncbi.nlm.nih.gov/pubmed/34133849
http://dx.doi.org/10.1002/acn3.51407
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