No strong HLA association with MOG antibody disease in the UK population

Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG‐antibody‐associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis i...

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Autores principales: Grant‐Peters, Melissa, Passos, Giordani Rodrigues Dos, Yeung, Hing‐Yuen, Jacob, Anu, Huda, Saif, Leite, Maria Isabel, Dendrou, Calliope A., Palace, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283171/
https://www.ncbi.nlm.nih.gov/pubmed/33991459
http://dx.doi.org/10.1002/acn3.51378
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author Grant‐Peters, Melissa
Passos, Giordani Rodrigues Dos
Yeung, Hing‐Yuen
Jacob, Anu
Huda, Saif
Leite, Maria Isabel
Dendrou, Calliope A.
Palace, Jacqueline
author_facet Grant‐Peters, Melissa
Passos, Giordani Rodrigues Dos
Yeung, Hing‐Yuen
Jacob, Anu
Huda, Saif
Leite, Maria Isabel
Dendrou, Calliope A.
Palace, Jacqueline
author_sort Grant‐Peters, Melissa
collection PubMed
description Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG‐antibody‐associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti‐MOG antibody generation. A weak protective association of HLA‐C*03:04 was observed (OR = 0.26, 95% CI = 0.10‐0.71, p(c)  = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology.
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spelling pubmed-82831712021-07-21 No strong HLA association with MOG antibody disease in the UK population Grant‐Peters, Melissa Passos, Giordani Rodrigues Dos Yeung, Hing‐Yuen Jacob, Anu Huda, Saif Leite, Maria Isabel Dendrou, Calliope A. Palace, Jacqueline Ann Clin Transl Neurol Brief Communications Improvements in assays for detecting serum antibodies against myelin oligodendrocyte glycoprotein (MOG) have led to the appreciation of MOG‐antibody‐associated disease (MOGAD) as a novel disorder. However, much remains unknown about its etiology. We performed human leukocyte antigen (HLA) analysis in 82 MOGAD patients of European ancestry in the UK population. No HLA class II associations were observed, thus questioning the mechanism of anti‐MOG antibody generation. A weak protective association of HLA‐C*03:04 was observed (OR = 0.26, 95% CI = 0.10‐0.71, p(c)  = 0.013), suggesting a need for continued efforts to better understand MOGAD genetics and pathophysiology. John Wiley and Sons Inc. 2021-05-15 /pmc/articles/PMC8283171/ /pubmed/33991459 http://dx.doi.org/10.1002/acn3.51378 Text en © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Grant‐Peters, Melissa
Passos, Giordani Rodrigues Dos
Yeung, Hing‐Yuen
Jacob, Anu
Huda, Saif
Leite, Maria Isabel
Dendrou, Calliope A.
Palace, Jacqueline
No strong HLA association with MOG antibody disease in the UK population
title No strong HLA association with MOG antibody disease in the UK population
title_full No strong HLA association with MOG antibody disease in the UK population
title_fullStr No strong HLA association with MOG antibody disease in the UK population
title_full_unstemmed No strong HLA association with MOG antibody disease in the UK population
title_short No strong HLA association with MOG antibody disease in the UK population
title_sort no strong hla association with mog antibody disease in the uk population
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283171/
https://www.ncbi.nlm.nih.gov/pubmed/33991459
http://dx.doi.org/10.1002/acn3.51378
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