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Neural-ODE for pharmacokinetics modeling and its advantage to alternative machine learning models in predicting new dosing regimens
Forecasting pharmacokinetics (PK) for individual patients is a fundamental problem in clinical pharmacology. One key challenge is that PK models constructed using data from one dosing regimen must predict PK data for different dosing regimen(s). We propose a deep learning approach based on neural or...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283337/ https://www.ncbi.nlm.nih.gov/pubmed/34308294 http://dx.doi.org/10.1016/j.isci.2021.102804 |