Cargando…

Safety and Preliminary Efficacy of Lorcaserin for Cocaine Use Disorder: A Phase I Randomized Clinical Trial

Background and Objectives: Preclinical studies show serotonin (5-HT) 5-HT(2C) receptor (5-HT(2C)R) agonists reduce cocaine-seeking and cocaine intake. This study examined safety of the 5-HT(2C)R agonist lorcaserin administered with cocaine in participants with cocaine use disorder (CocUD). Secondari...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johns, Sade E., Keyser-Marcus, Lori, Abbate, Antonio, Boone, Edward, Van Tassell, Benjamin, Cunningham, Kathryn A., Anastasio, Noelle C., Poklis, Justin L., Ramey, Tatiana, Moeller, F. Gerard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283411/ https://www.ncbi.nlm.nih.gov/pubmed/34276440 http://dx.doi.org/10.3389/fpsyt.2021.666945

Ejemplares similares

Methylation Patterns of the HTR2A Associate With Relapse-Related Behaviors in Cocaine-Dependent Participants
por: Land, Michelle A., et al.
Publicado: (2020)

2438: Dose-dependent nature of cocaine infusions on cardiovascular hemodynamics
por: Carbone, Salvatore, et al.
Publicado: (2018)

Social Information Processing in Substance Use Disorders: Insights From an Emotional Go-Nogo Task
por: Bjork, James M., et al.
Publicado: (2021)

Pimavanserin and Lorcaserin Attenuate Measures of Binge Eating in Male Sprague-Dawley Rats
por: Price, Amanda E., et al.
Publicado: (2018)

Sex Specific Sleep Parameters Among People With Substance Use Disorder
por: Martin, Caitlin E., et al.
Publicado: (2022)

Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study
por: Nielsen, David A., et al.
Publicado: (2012)

Combination of Modafinil and d-amphetamine for the Treatment of Cocaine Dependence: A Preliminary Investigation
por: Schmitz, Joy M., et al.
Publicado: (2012)

Preliminary Findings of Weaker Executive Control Network Resting State fMRI Functional Connectivity in Opioid Use Disorder compared to Healthy Controls
por: Woisard, Kyle, et al.
Publicado: (2021)

Lorcaserin for weight management
por: Taylor, James R, et al.
Publicado: (2013)

Ghrelin receptor antagonist JMV2959 blunts cocaine and oxycodone drug-seeking, but not self-administration, in male rats
por: Merritt, Christina R., et al.
Publicado: (2023)

Behavioral and neurocognitive factors distinguishing post-traumatic stress comorbidity in substance use disorders
por: Houghton, David C., et al.
Publicado: (2023)

A serotonergic biobehavioral signature differentiates cocaine use disorder participants administered mirtazapine
por: Ma, Liangsuo, et al.
Publicado: (2022)

Utility of Machine-Learning Approaches to Identify Behavioral Markers for Substance Use Disorders: Impulsivity Dimensions as Predictors of Current Cocaine Dependence
por: Ahn, Woo-Young, et al.
Publicado: (2016)

The Influence of Baseline Marijuana Use on Treatment of Cocaine Dependence: Application of an Informative-Priors Bayesian Approach
por: Green, Charles, et al.
Publicado: (2012)

Lorcaserin: A novel antiobesity drug
por: Brashier, Dick B. S., et al.
Publicado: (2014)

Executive control network resting state fMRI functional and effective connectivity and delay discounting in cocaine dependent subjects compared to healthy controls
por: Woisard, Kyle, et al.
Publicado: (2023)

Preclinical Assessment of Lisdexamfetamine as an Agonist Medication Candidate for Cocaine Addiction: Effects in Rhesus Monkeys Trained to Discriminate Cocaine or to Self-Administer Cocaine in a Cocaine Versus Food Choice Procedure
por: Banks, Matthew L., et al.
Publicado: (2015)

Inhibition of Cocaine and 3,4-Methylenedioxypyrovalerone (MDPV) Self-Administration by Lorcaserin Is Mediated by 5-HT2C Receptors in Rats
por: Gannon, Brenda M., et al.
Publicado: (2018)

Cocaine Exposure and Children's Self-Regulation: Indirect Association via Maternal Harshness
por: Eiden, Rina D., et al.
Publicado: (2011)

Lorcaserin improves glycemic control via a melanocortin neurocircuit
por: Burke, Luke K., et al.
Publicado: (2017)

Elevated Expression of Serotonin 5-HT(2A) Receptors in the Rat Ventral Tegmental Area Enhances Vulnerability to the Behavioral Effects of Cocaine
por: Herin, David V., et al.
Publicado: (2013)

The use of lorcaserin in the management of obesity: a critical appraisal
por: Bai, Bo, et al.
Publicado: (2010)

Increased Orbitofrontal Brain Activation after Administration of a Selective Adenosine A(2A) Antagonist in Cocaine Dependent Subjects
por: Moeller, F. Gerard, et al.
Publicado: (2012)

Heightened cocaine-seeking in male rats associates with a distinct transcriptomic profile in the medial prefrontal cortex
por: Merritt, Christina R., et al.
Publicado: (2022)

Sex Differences in Psychiatric Comorbidity and Plasma Biomarkers for Cocaine Addiction in Abstinent Cocaine-Addicted Subjects in Outpatient Settings
por: Pedraz, María, et al.
Publicado: (2015)

Social and Non-Social Cognitive Enhancement in Cocaine Users—A Closer Look on Enhancement Motives for Cocaine Consumption
por: Kexel, Ann-Kathrin, et al.
Publicado: (2020)

Higher Impulsivity As a Distinctive Trait of Severe Cocaine Addiction among Individuals Treated for Cocaine or Alcohol Use Disorders
por: García-Marchena, Nuria, et al.
Publicado: (2018)

State-Dependent Effects of Ventromedial Prefrontal Cortex Continuous Thetaburst Stimulation on Cocaine Cue Reactivity in Chronic Cocaine Users
por: Kearney-Ramos, Tonisha E., et al.
Publicado: (2019)

Challenging obesity, diabetes, and addiction: the potential of lorcaserin extended release
por: Hurt, Ryan T, et al.
Publicado: (2018)

Lorcaserin and metabolic disease: weight‐loss dependent and independent effects
por: Bays, H., et al.
Publicado: (2018)

Dyadic Social Interaction as an Alternative Reward to Cocaine
por: Zernig, Gerald, et al.
Publicado: (2013)

BDNF and Cortisol in the Diagnosis of Cocaine-Induced Depression
por: Fonseca, Francina, et al.
Publicado: (2022)

Enhanced Amygdala-Striatal Functional Connectivity during the Processing of Cocaine Cues in Male Cocaine Users with a History of Childhood Trauma
por: Kaag, Anne Marije, et al.
Publicado: (2018)

rTMS Reduces Psychopathological Burden and Cocaine Consumption in Treatment-Seeking Subjects With Cocaine Use Disorder: An Open Label, Feasibility Study
por: Pettorruso, Mauro, et al.
Publicado: (2019)

Prenatal IV Cocaine: Alterations in Auditory Information Processing
por: Mactutus, Charles F., et al.
Publicado: (2011)

An Examination of the Feasibility of Detecting Cocaine Use Using Smartwatches
por: Ertin, Emre, et al.
Publicado: (2021)

Lorcaserin for the treatment of obesity? A closer look at its side effects
por: DiNicolantonio, James J, et al.
Publicado: (2014)

Lorcaserin therapy for severe epilepsy of childhood onset: A case series
por: Tolete, Patricia, et al.
Publicado: (2018)

Lorcaserin and phentermine exert anti-obesity effects with modulation of the gut microbiota
por: Song, Eun-Ji, et al.
Publicado: (2023)

Can Ropinirole Modulate Reinforcing Subjective Effects of Cocaine in Humans?
por: Maremmani, Angelo Giovanni Icro, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_j1g4b2e81lgkb0693s3l1n2cd0