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Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population
BACKGROUND/AIM: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acromegaly-related comorbidities, and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Scientific and Technological Research Council of Turkey
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283474/ https://www.ncbi.nlm.nih.gov/pubmed/33389987 http://dx.doi.org/10.3906/sag-2007-243 |
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author | CAN, Mustafa KOCABAŞ, Muhammet ÇORDAN, İlker ÇALIŞKAN BURGUCU, Hatice KARAKÖSE, Melia KULAKSIZOĞLU, Mustafa KARAKURT, Feridun |
author_facet | CAN, Mustafa KOCABAŞ, Muhammet ÇORDAN, İlker ÇALIŞKAN BURGUCU, Hatice KARAKÖSE, Melia KULAKSIZOĞLU, Mustafa KARAKURT, Feridun |
author_sort | CAN, Mustafa |
collection | PubMed |
description | BACKGROUND/AIM: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acromegaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly. MATERIALS AND METHODS: In the study, 96 patients who were followed up with the diagnosis of acromegaly were included. Clinical, laboratory and imaging features, and accompanying comorbidities of the patients were recorded from the patient files. RESULTS: Of the patients included in the study, 63 (65.6%) were female and 33 (34.4%) were male. The mean age of diagnosis was 42.61± 12.08, and the mean follow-up period was 9.97 ± 7.26 years. Median insulin-like growth factor 1 level was 238.16 ng/mL (30.5–820), median growth hormone level was 2.05 ug/L (0.1–29.4). A total of 60 (62.5%) of the patients were in the well-controlled group, and 36 (37.5%) had active disease at the time of inclusion. Diabetes mellitus (DM) was detected in 30 (31.3%) patients, prediabetes in 19 (28.8%) patients, hypertriglyceridemia in 38 (42.2%) patients, hypertension (HT) in 41 (42.7%) patients, cardiovascular disease in 5 (5.2%) patients, malignancy in 9 (9.4%) patients, obstructive sleep apnea syndrome in 8 (8.3%) patients, carpal tunnel syndrome in 11 (11.5%) patients, arthropathy in 5 (5.2%) patients, hearing loss in 7 (7.3%) patients, thyroid nodule in 56 (67.5%) patients, thyroid cancer in 4 (4.2%) patients, colonic polyp in 19 (38.8%) patients. CONCLUSION: In this study, we revealed that the most common comorbidities in acromegaly patients in the Turkish population are thyroid nodules, low high-density lipoprotein (HDL cholesterol (HDL-C) level, hypertriglyceridemia, HT, colonic polyps, DM, and prediabetes, and female sex and age at diagnosis are the most important factors associated with comorbidities. |
format | Online Article Text |
id | pubmed-8283474 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Scientific and Technological Research Council of Turkey |
record_format | MEDLINE/PubMed |
spelling | pubmed-82834742021-08-02 Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population CAN, Mustafa KOCABAŞ, Muhammet ÇORDAN, İlker ÇALIŞKAN BURGUCU, Hatice KARAKÖSE, Melia KULAKSIZOĞLU, Mustafa KARAKURT, Feridun Turk J Med Sci Article BACKGROUND/AIM: The presence of comorbidities in patients with acromegaly causes an increase in morbidity and/or mortality and a decrease in quality of life. In this study, we aimed to investigate the demographic, clinical and laboratory features, prevalence of acromegaly-related comorbidities, and factors associated with these comorbidities in patients with acromegaly. MATERIALS AND METHODS: In the study, 96 patients who were followed up with the diagnosis of acromegaly were included. Clinical, laboratory and imaging features, and accompanying comorbidities of the patients were recorded from the patient files. RESULTS: Of the patients included in the study, 63 (65.6%) were female and 33 (34.4%) were male. The mean age of diagnosis was 42.61± 12.08, and the mean follow-up period was 9.97 ± 7.26 years. Median insulin-like growth factor 1 level was 238.16 ng/mL (30.5–820), median growth hormone level was 2.05 ug/L (0.1–29.4). A total of 60 (62.5%) of the patients were in the well-controlled group, and 36 (37.5%) had active disease at the time of inclusion. Diabetes mellitus (DM) was detected in 30 (31.3%) patients, prediabetes in 19 (28.8%) patients, hypertriglyceridemia in 38 (42.2%) patients, hypertension (HT) in 41 (42.7%) patients, cardiovascular disease in 5 (5.2%) patients, malignancy in 9 (9.4%) patients, obstructive sleep apnea syndrome in 8 (8.3%) patients, carpal tunnel syndrome in 11 (11.5%) patients, arthropathy in 5 (5.2%) patients, hearing loss in 7 (7.3%) patients, thyroid nodule in 56 (67.5%) patients, thyroid cancer in 4 (4.2%) patients, colonic polyp in 19 (38.8%) patients. CONCLUSION: In this study, we revealed that the most common comorbidities in acromegaly patients in the Turkish population are thyroid nodules, low high-density lipoprotein (HDL cholesterol (HDL-C) level, hypertriglyceridemia, HT, colonic polyps, DM, and prediabetes, and female sex and age at diagnosis are the most important factors associated with comorbidities. The Scientific and Technological Research Council of Turkey 2021-06-28 /pmc/articles/PMC8283474/ /pubmed/33389987 http://dx.doi.org/10.3906/sag-2007-243 Text en Copyright © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Article CAN, Mustafa KOCABAŞ, Muhammet ÇORDAN, İlker ÇALIŞKAN BURGUCU, Hatice KARAKÖSE, Melia KULAKSIZOĞLU, Mustafa KARAKURT, Feridun Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title | Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title_full | Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title_fullStr | Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title_full_unstemmed | Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title_short | Prevalence of comorbidities and associated factors in acromegaly patients in the Turkish population |
title_sort | prevalence of comorbidities and associated factors in acromegaly patients in the turkish population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283474/ https://www.ncbi.nlm.nih.gov/pubmed/33389987 http://dx.doi.org/10.3906/sag-2007-243 |
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