Study protocol for a phase 2A trial of the safety and tolerability of increased dose rifampicin and adjunctive linezolid, with or without aspirin, for HIV-associated tuberculous meningitis [LASER-TBM]

Background: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not account for the differing ability of the drugs to penetrate the c...

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Detalles Bibliográficos
Autores principales: Davis, Angharad G., Wasserman, Sean, Maxebengula, Mpumi, Stek, Cari, Bremer, Marise, Daroowala, Remy, Aziz, Saalikha, Goliath, Rene, Stegmann, Stephani, Koekemoer, Sonya, Jackson, Amanda, Lai Sai, Louise, Kadernani, Yakub, Sihoyiya, Thandi, Liang, C.Jason, Dodd, Lori, Denti, Paolo, Crede, Thomas, Naude, Jonathan, Szymanski, Patryk, Vallie, Yakoob, Banderker, Ismail, Moosa, Shiraz, Raubenheimer, Peter, Lai, Rachel P.J., Joska, John, Nightingale, Sam, Dreyer, Anna, Wahl, Gerda, Offiah, Curtis, Vorster, Isak, Candy, Sally, Robertson, Frances, Meintjes, Ernesta, Maartens, Gary, Black, John, Meintjes, Graeme, Wilkinson, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2021
Materias:
Study Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283551/
https://www.ncbi.nlm.nih.gov/pubmed/34286103
http://dx.doi.org/10.12688/wellcomeopenres.16783.1

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