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Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report
BACKGROUND: Adenoid cystic carcinoma (ACC) is a common malignant tumor of salivary gland. The lung and liver are frequent sites of distant metastasis. Liver metastasis as the initial clinical manifestation of sublingual gland ACC is very rare. CASE SUMMARY: A 51-year-old Chinese woman presented with...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283605/ https://www.ncbi.nlm.nih.gov/pubmed/34307573 http://dx.doi.org/10.12998/wjcc.v9.i19.5238 |
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author | Li, Xiao-Hong Zhang, Yu-Tao Feng, Hao |
author_facet | Li, Xiao-Hong Zhang, Yu-Tao Feng, Hao |
author_sort | Li, Xiao-Hong |
collection | PubMed |
description | BACKGROUND: Adenoid cystic carcinoma (ACC) is a common malignant tumor of salivary gland. The lung and liver are frequent sites of distant metastasis. Liver metastasis as the initial clinical manifestation of sublingual gland ACC is very rare. CASE SUMMARY: A 51-year-old Chinese woman presented with a painless mass in the right lobe of liver. The tumor was composed of ductal cells and myoepithelial cells with a morphology including tubiform and cribriform structures. Immunostaining results showed ductal cells positive for CK7, CK14, CK19, CD117, and 34βE12, and negative for MYB, vimentin, ER, PR, and CEA. The myoepithelial cells were positive for p63, calponin and CK5/6. Metastatic salivary ACC was considered, and a sublingual gland mass was revealed by computed tomography. Histological evaluation confirmed primary sublingual gland ACC. Fluorescence in situ hybridization (FISH) did not find an MYB-NFIB fusion gene in specimens from either the primary or metastatic ACC tumors. The sublingual gland ACC relapsed in 20 mo. The recurrent lesion disappeared following local radiation therapy and computed tomography-guided radioactive seed implantation. The patient remains in good condition until now. CONCLUSION: Metastatic sublingual gland ACC with initial clinical manifestation as a liver mass is very rare, and was pathologically confirmed in this patient by its histological appearance. Primary hepatic tumors and metastatic carcinomas should be included in the differential diagnosis. Immunohistochemical detection of MYB protein and MYB-NFIB fusion gene detection by FISH can be helpful, but occasional negative results confuse the diagnosis. |
format | Online Article Text |
id | pubmed-8283605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-82836052021-07-23 Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report Li, Xiao-Hong Zhang, Yu-Tao Feng, Hao World J Clin Cases Case Report BACKGROUND: Adenoid cystic carcinoma (ACC) is a common malignant tumor of salivary gland. The lung and liver are frequent sites of distant metastasis. Liver metastasis as the initial clinical manifestation of sublingual gland ACC is very rare. CASE SUMMARY: A 51-year-old Chinese woman presented with a painless mass in the right lobe of liver. The tumor was composed of ductal cells and myoepithelial cells with a morphology including tubiform and cribriform structures. Immunostaining results showed ductal cells positive for CK7, CK14, CK19, CD117, and 34βE12, and negative for MYB, vimentin, ER, PR, and CEA. The myoepithelial cells were positive for p63, calponin and CK5/6. Metastatic salivary ACC was considered, and a sublingual gland mass was revealed by computed tomography. Histological evaluation confirmed primary sublingual gland ACC. Fluorescence in situ hybridization (FISH) did not find an MYB-NFIB fusion gene in specimens from either the primary or metastatic ACC tumors. The sublingual gland ACC relapsed in 20 mo. The recurrent lesion disappeared following local radiation therapy and computed tomography-guided radioactive seed implantation. The patient remains in good condition until now. CONCLUSION: Metastatic sublingual gland ACC with initial clinical manifestation as a liver mass is very rare, and was pathologically confirmed in this patient by its histological appearance. Primary hepatic tumors and metastatic carcinomas should be included in the differential diagnosis. Immunohistochemical detection of MYB protein and MYB-NFIB fusion gene detection by FISH can be helpful, but occasional negative results confuse the diagnosis. Baishideng Publishing Group Inc 2021-07-06 2021-07-06 /pmc/articles/PMC8283605/ /pubmed/34307573 http://dx.doi.org/10.12998/wjcc.v9.i19.5238 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Case Report Li, Xiao-Hong Zhang, Yu-Tao Feng, Hao Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title | Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title_full | Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title_fullStr | Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title_full_unstemmed | Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title_short | Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report |
title_sort | liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283605/ https://www.ncbi.nlm.nih.gov/pubmed/34307573 http://dx.doi.org/10.12998/wjcc.v9.i19.5238 |
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