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2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

BACKGROUND: High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the clearance of invading pulmonary pathogens and dying neutrophils in the injured lungs...

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Detalles Bibliográficos
Autores principales:	Wang, Mao, Gauthier, Alex G., Kennedy, Thomas P., Wang, Haichao, Velagapudi, Uday Kiran, Talele, Tanaji T., Lin, Mosi, Wu, Jiaqi, Daley, LeeAnne, Yang, Xiaojing, Patel, Vivek, Mun, Sung Soo, Ashby, Charles R., Mantell, Lin L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283750/ https://www.ncbi.nlm.nih.gov/pubmed/34271850 http://dx.doi.org/10.1186/s10020-021-00334-y

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