Identification of a Core Amino Acid Motif within the α Subunit of GABA(A)Rs that Promotes Inhibitory Synaptogenesis and Resilience to Seizures

SUMMARY: The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABA(A)Rs) at the appropriate synaptic sites. Synaptic GABA(A)Rs are constructed from α(1–3), β(1–3), and γ2 subunits, and neurons can target these subtypes to specific syn...

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Detalles Bibliográficos
Autores principales: Nathanson, Anna J., Zhang, Yihui, Smalley, Joshua L., Ollerhead, Thomas A., Santos, Miguel A. Rodriguez, Andrews, Peter M., Wobst, Heike J., Moore, Yvonne E., Brandon, Nicholas J., Hines, Rochelle M., Davies, Paul A., Moss, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283774/
https://www.ncbi.nlm.nih.gov/pubmed/31315046
http://dx.doi.org/10.1016/j.celrep.2019.06.014

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