PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway

A classical hallmark of Parkinson’s disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive. Previously, we identified that...

Descripción completa

Detalles Bibliográficos
Autores principales: Samidurai, Manikandan, Palanisamy, Bharathi N., Bargues-Carot, Alejandra, Hepker, Monica, Kondru, Naveen, Manne, Sireesha, Zenitsky, Gary, Jin, Huajun, Anantharam, Vellareddy, Kanthasamy, Anumantha G., Kanthasamy, Arthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283807/
https://www.ncbi.nlm.nih.gov/pubmed/34276337
http://dx.doi.org/10.3389/fnagi.2021.661505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283807/
https://www.ncbi.nlm.nih.gov/pubmed/34276337
http://dx.doi.org/10.3389/fnagi.2021.661505

Ejemplares similares