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Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease

In this work, we present the first steps toward the creation of a new neurorobotics model of Parkinson's Disease (PD) that embeds, for the first time in a real robot, a well-established computational model of PD. PD mostly affects the modulation of movement in humans. The number of people suffe...

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Autores principales: Pimentel, Jhielson M., Moioli, Renan C., de Araujo, Mariana F. P., Ranieri, Caetano M., Romero, Roseli A. F., Broz, Frank, Vargas, Patricia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283825/
https://www.ncbi.nlm.nih.gov/pubmed/34276331
http://dx.doi.org/10.3389/fnbot.2021.640449
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author Pimentel, Jhielson M.
Moioli, Renan C.
de Araujo, Mariana F. P.
Ranieri, Caetano M.
Romero, Roseli A. F.
Broz, Frank
Vargas, Patricia A.
author_facet Pimentel, Jhielson M.
Moioli, Renan C.
de Araujo, Mariana F. P.
Ranieri, Caetano M.
Romero, Roseli A. F.
Broz, Frank
Vargas, Patricia A.
author_sort Pimentel, Jhielson M.
collection PubMed
description In this work, we present the first steps toward the creation of a new neurorobotics model of Parkinson's Disease (PD) that embeds, for the first time in a real robot, a well-established computational model of PD. PD mostly affects the modulation of movement in humans. The number of people suffering from this neurodegenerative disease is set to double in the next 15 years and there is still no cure. With the new model we were capable to further explore the dynamics of the disease using a humanoid robot. Results show that the embedded model under both conditions, healthy and parkinsonian, was capable of performing a simple behavioural task with different levels of motor disturbance. We believe that this neurorobotics model is a stepping stone to the development of more sophisticated models that could eventually test and inform new PD therapies and help to reduce and replace animals in research.
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spelling pubmed-82838252021-07-17 Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease Pimentel, Jhielson M. Moioli, Renan C. de Araujo, Mariana F. P. Ranieri, Caetano M. Romero, Roseli A. F. Broz, Frank Vargas, Patricia A. Front Neurorobot Neuroscience In this work, we present the first steps toward the creation of a new neurorobotics model of Parkinson's Disease (PD) that embeds, for the first time in a real robot, a well-established computational model of PD. PD mostly affects the modulation of movement in humans. The number of people suffering from this neurodegenerative disease is set to double in the next 15 years and there is still no cure. With the new model we were capable to further explore the dynamics of the disease using a humanoid robot. Results show that the embedded model under both conditions, healthy and parkinsonian, was capable of performing a simple behavioural task with different levels of motor disturbance. We believe that this neurorobotics model is a stepping stone to the development of more sophisticated models that could eventually test and inform new PD therapies and help to reduce and replace animals in research. Frontiers Media S.A. 2021-07-01 /pmc/articles/PMC8283825/ /pubmed/34276331 http://dx.doi.org/10.3389/fnbot.2021.640449 Text en Copyright © 2021 Pimentel, Moioli, de Araujo, Ranieri, Romero, Broz and Vargas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Pimentel, Jhielson M.
Moioli, Renan C.
de Araujo, Mariana F. P.
Ranieri, Caetano M.
Romero, Roseli A. F.
Broz, Frank
Vargas, Patricia A.
Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title_full Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title_fullStr Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title_full_unstemmed Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title_short Neuro4PD: An Initial Neurorobotics Model of Parkinson's Disease
title_sort neuro4pd: an initial neurorobotics model of parkinson's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8283825/
https://www.ncbi.nlm.nih.gov/pubmed/34276331
http://dx.doi.org/10.3389/fnbot.2021.640449
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