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COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study
BACKGROUND: Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases. This study’s objective was thus to explore whether a correlation exists between COVID-19 viral loa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284033/ https://www.ncbi.nlm.nih.gov/pubmed/34271860 http://dx.doi.org/10.1186/s12879-021-06376-1 |
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author | Abdulrahman, Abdulkarim Mallah, Saad I. Alqahtani, Manaf |
author_facet | Abdulrahman, Abdulkarim Mallah, Saad I. Alqahtani, Manaf |
author_sort | Abdulrahman, Abdulkarim |
collection | PubMed |
description | BACKGROUND: Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases. This study’s objective was thus to explore whether a correlation exists between COVID-19 viral loads, as indicated by RT-PCR Ct values, and disease severity, as indicated by respiratory indices. RESULTS: A multi-centre cross-sectional retrospective study was conducted, using data obtained from Bahrain’s National COVID-19 Task force’s centralised database. The study period ranged from May 2, 2020 to July 31, 2020. A multivariable logistic regression was used to assess for a correlation using data from a total of 1057 admitted COVID-19 cases. The covariates adjusted for included sex, age, presentation, and comorbidities. In our cohort, Ct value showed no statistical significance for an association with requirement for oxygenation on admission (Odds ratio 1.046; 95%CI 0.999 to 1.096, p = 0.054). CONCLUSION: Viral load, as indicated by Ct values, did not seem to be associated with requirement for oxygenation on admission in our cohort. We postulate however that time since onset of symptom may have acted as an unaccounted-for confounder. As such, RT-PCR Ct values may not be a useful prognostic clinical tool in isolation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06376-1. |
format | Online Article Text |
id | pubmed-8284033 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82840332021-07-19 COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study Abdulrahman, Abdulkarim Mallah, Saad I. Alqahtani, Manaf BMC Infect Dis Research BACKGROUND: Being able to use COVID-19 RT-PCR Ct values as simple clinical markers of disease outcome or prognosis would allow for the easy and proactive identification and triaging of high-risk cases. This study’s objective was thus to explore whether a correlation exists between COVID-19 viral loads, as indicated by RT-PCR Ct values, and disease severity, as indicated by respiratory indices. RESULTS: A multi-centre cross-sectional retrospective study was conducted, using data obtained from Bahrain’s National COVID-19 Task force’s centralised database. The study period ranged from May 2, 2020 to July 31, 2020. A multivariable logistic regression was used to assess for a correlation using data from a total of 1057 admitted COVID-19 cases. The covariates adjusted for included sex, age, presentation, and comorbidities. In our cohort, Ct value showed no statistical significance for an association with requirement for oxygenation on admission (Odds ratio 1.046; 95%CI 0.999 to 1.096, p = 0.054). CONCLUSION: Viral load, as indicated by Ct values, did not seem to be associated with requirement for oxygenation on admission in our cohort. We postulate however that time since onset of symptom may have acted as an unaccounted-for confounder. As such, RT-PCR Ct values may not be a useful prognostic clinical tool in isolation. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06376-1. BioMed Central 2021-07-16 /pmc/articles/PMC8284033/ /pubmed/34271860 http://dx.doi.org/10.1186/s12879-021-06376-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Abdulrahman, Abdulkarim Mallah, Saad I. Alqahtani, Manaf COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title | COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title_full | COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title_fullStr | COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title_full_unstemmed | COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title_short | COVID-19 viral load not associated with disease severity: findings from a retrospective cohort study |
title_sort | covid-19 viral load not associated with disease severity: findings from a retrospective cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284033/ https://www.ncbi.nlm.nih.gov/pubmed/34271860 http://dx.doi.org/10.1186/s12879-021-06376-1 |
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