Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit

We describe a pre-clinical spinal cord motor neuron injury model that is minimal invasive, reproducible, focal and easily applied to small rodents. Retrograde axonal transport of a pro-apoptotic phosphatidylinosotol 3’-kinase inhibitor, wortmannin, via the sciatic nerve results in loss of ipsilatera...

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Detalles Bibliográficos
Autores principales: Liang, Allison S., Pagano, Joanna E., Chrzan, Christopher A., McKinnon, Randall D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284299/
https://www.ncbi.nlm.nih.gov/pubmed/33318406
http://dx.doi.org/10.4103/1673-5374.301032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284299/
https://www.ncbi.nlm.nih.gov/pubmed/33318406
http://dx.doi.org/10.4103/1673-5374.301032

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