Integrated Polygenic Tool Substantially Enhances Coronary Artery Disease Prediction

BACKGROUND: There is considerable interest in whether genetic data can be used to improve standard cardiovascular disease risk calculators, as the latter are routinely used in clinical practice to manage preventative treatment. METHODS: Using the UK Biobank resource, we developed our own polygenic r...

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Detalles Bibliográficos
Autores principales: Riveros-Mckay, Fernando, Weale, Michael E., Moore, Rachel, Selzam, Saskia, Krapohl, Eva, Sivley, R. Michael, Tarran, William A., Sørensen, Peter, Lachapelle, Alexander S., Griffiths, Jonathan A., Saffari, Ayden, Deanfield, John, Spencer, Chris C.A., Hippisley-Cox, Julia, Hunter, David J., O’Sullivan, Jack W., Ashley, Euan A., Plagnol, Vincent, Donnelly, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284388/
https://www.ncbi.nlm.nih.gov/pubmed/33651632
http://dx.doi.org/10.1161/CIRCGEN.120.003304

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