Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

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Neutralizing antibodies (nAbs) elicited against the receptor-binding site (RBS) of the spike protein of wild-type SARS-CoV-2 are generally less effective against recent variants of concern. RBS residues E484, K417 and N501 are mutated in variants first described in South Africa (B.1.351) and Brazil...

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Detalles Bibliográficos
Autores principales: Yuan, Meng, Huang, Deli, Lee, Chang-Chun D., Wu, Nicholas C., Jackson, Abigail M., Zhu, Xueyong, Liu, Hejun, Peng, Linghang, van Gils, Marit J., Sanders, Rogier W., Burton, Dennis R., Reincke, S. Momsen, Prüss, Harald, Kreye, Jakob, Nemazee, David, Ward, Andrew B., Wilson, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
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Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284396/
https://www.ncbi.nlm.nih.gov/pubmed/34016740
http://dx.doi.org/10.1126/science.abh1139
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