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Two β-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics

The β-lactamase of Mycobacterium tuberculosis, BlaC, is susceptible to inhibition by clavulanic acid. The ability of this enzyme to escape inhibition through mutation was probed using error-prone PCR combined with functional screening in Escherichia coli. The variant that was found to confer the mos...

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Detalles Bibliográficos
Autores principales:	Elings, Wouter, Chikunova, Aleksandra, van Zanten, Danny B., Drenth, Ralphe, Ahmad, Misbha Ud Din, Blok, Anneloes J., Timmer, Monika, Perrakis, Anastassis, Ubbink, Marcellus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2021
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284444/ https://www.ncbi.nlm.nih.gov/pubmed/34031049 http://dx.doi.org/10.1128/AAC.02628-20

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