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Progress and Challenges in the Biology of FNDC5 and Irisin

In 2002, a transmembrane protein—now known as FNDC5—was discovered and shown to be expressed in skeletal muscle, heart, and brain. It was virtually ignored for 10 years, until a study in 2012 proposed that, in response to exercise, the ectodomain of skeletal muscle FNDC5 was cleaved, traveled to whi...

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Detalles Bibliográficos
Autores principales:	Maak, Steffen, Norheim, Frode, Drevon, Christian A, Erickson, Harold P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284618/ https://www.ncbi.nlm.nih.gov/pubmed/33493316 http://dx.doi.org/10.1210/endrev/bnab003

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