Cargando…

Single-cell image analysis reveals a protective role for microglia in glioblastoma

BACKGROUND: Microglia and tumor-associated macrophages (TAMs) constitute up to half of the total tumor mass of glioblastomas. Despite these myeloid populations being ontogenetically distinct, they have been largely conflated. Recent single-cell transcriptomic studies have identified genes that disti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woolf, Zoe, Swanson, Molly E V, Smyth, Leon C, Mee, Edward W, Schweder, Patrick, Heppner, Peter, Kim, Bernard J H, Turner, Clinton, Oldfield, Robyn L, Curtis, Maurice A, Faull, Richard L M, Scotter, Emma L, Park, Thomas I-H, Dragunow, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284623/ https://www.ncbi.nlm.nih.gov/pubmed/34286275 http://dx.doi.org/10.1093/noajnl/vdab031

Ejemplares similares

Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue
por: Cooper, Elizabeth, et al.
Publicado: (2022)

Isolation of highly enriched primary human microglia for functional studies
por: Rustenhoven, Justin, et al.
Publicado: (2016)

PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
por: Rustenhoven, Justin, et al.
Publicado: (2018)

Cardiac glycosides target barrier inflammation of the vasculature, meninges and choroid plexus
por: Jansson, Deidre, et al.
Publicado: (2021)

Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis
por: Swanson, Molly E. V., et al.
Publicado: (2020)

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia
por: Smith, Amy M, et al.
Publicado: (2013)

Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress
por: Stevenson, Taylor J., et al.
Publicado: (2022)

Isolation and culture of functional adult human neurons from neurosurgical brain specimens
por: Park, Thomas I-H, et al.
Publicado: (2020)

Quantitative immunohistochemical analysis of myeloid cell marker expression in human cortex captures microglia heterogeneity with anatomical context
por: Swanson, Molly E. V., et al.
Publicado: (2020)

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function
por: Rustenhoven, Justin, et al.
Publicado: (2016)

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction
por: Rustenhoven, Justin, et al.
Publicado: (2018)

Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy
por: Smith, Amy M., et al.
Publicado: (2022)

An anti-inflammatory role for C/EBPδ in human brain pericytes
por: Rustenhoven, Justin, et al.
Publicado: (2015)

Unique and shared inflammatory profiles of human brain endothelia and pericytes
por: Smyth, Leon C. D., et al.
Publicado: (2018)

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes
por: Jansson, Deidre, et al.
Publicado: (2016)

Isolation of adult mouse microglia using their in vitro adherent properties
por: Woolf, Zoe, et al.
Publicado: (2021)

Blood-spinal cord barrier leakage is independent of motor neuron pathology in ALS
por: Waters, Sarah, et al.
Publicado: (2021)

Microglial CD68 and L-ferritin upregulation in response to phosphorylated-TDP-43 pathology in the amyotrophic lateral sclerosis brain
por: Swanson, Molly E. V., et al.
Publicado: (2023)

Adult Human Glia, Pericytes and Meningeal Fibroblasts Respond Similarly to IFNy but Not to TGFβ(1) or M-CSF
por: Smith, Amy M., et al.
Publicado: (2013)

Days gained response discriminates treatment response in patients with recurrent glioblastoma receiving bevacizumab-based therapies
por: Singleton, Kyle W, et al.
Publicado: (2020)

Targeting the TREM1-positive myeloid microenvironment in glioblastoma
por: Filippova, Natalia, et al.
Publicado: (2022)

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data
por: Ajaib, Shoaib, et al.
Publicado: (2023)

Molecular profiles and immunomodulatory activities of glioblastoma-derived exosomes
por: Azambuja, Juliana Hofstatter, et al.
Publicado: (2020)

Proteins inform survival-based differences in patients with glioblastoma
por: Stetson, L C, et al.
Publicado: (2020)

Multireceptor targeting of glioblastoma
por: Sharma, Puja, et al.
Publicado: (2020)

Functional connectivity within glioblastoma impacts overall survival
por: Daniel, Andy G S, et al.
Publicado: (2020)

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022)

An affinity for brainstem microglia in pediatric high-grade gliomas of brainstem origin
por: Zats, Liat Peretz, et al.
Publicado: (2022)

Surgical resection of glioblastomas induces pleiotrophin-mediated self-renewal of glioblastoma stem cells in recurrent tumors
por: Knudsen, Arnon Møldrup, et al.
Publicado: (2021)

The EGFRvIII transcriptome in glioblastoma: A meta-omics analysis
por: Hoogstrate, Youri, et al.
Publicado: (2021)

Impact of the Patient Protection and Affordable Care Act on 1-year survival in glioblastoma patients
por: Moghavem, Nuriel, et al.
Publicado: (2020)

Erratum to: A role for human brain pericytes in neuroinflammation
por: Jansson, Deidre, et al.
Publicado: (2015)

A role for human brain pericytes in neuroinflammation
por: Jansson, Deidre, et al.
Publicado: (2014)

Simultaneous targeting of DNA replication and homologous recombination in glioblastoma with a polyether ionophore
por: Lim, Yi Chieh, et al.
Publicado: (2020)

Mitochondrial 1555 G>A variant as a potential risk factor for childhood glioblastoma
por: Li, Shaobo, et al.
Publicado: (2022)

Identification and functional prediction of mitochondrial complex III and IV mutations associated with glioblastoma
por: Lloyd, Rhiannon E., et al.
Publicado: (2015)

Genetic variations in EGF and EGFR and glioblastoma outcome
por: Sjöström, Sara, et al.
Publicado: (2010)

CRN2 enhances the invasiveness of glioblastoma cells
por: Ziemann, Anja, et al.
Publicado: (2013)

GammaTile® brachytherapy in the treatment of recurrent glioblastomas
por: Gessler, Dominic J, et al.
Publicado: (2021)

Expression of pluripotency-related genes in human glioblastoma
por: Rios, Álvaro Fabrício Lopes, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_20hvgj9qtpb6hbdbqopk0mpp5l