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Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study)
Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter stud...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284690/ https://www.ncbi.nlm.nih.gov/pubmed/34272635 http://dx.doi.org/10.1007/s11239-021-02527-y |
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author | García de Guadiana-Romualdo, Luis Morell-García, Daniel Favaloro, Emmanuel J. Vílchez, Juan A. Bauça, Josep M. Alcaide Martín, María J. Gutiérrez Garcia, Irene de la Hera Cagigal, Patricia Egea-Caparrós, José Manuel Pérez Sanmartín, Sonia Gutiérrez Revilla, José I. Urrechaga, Eloísa Álamo, Jose M. Hernando Holgado, Ana M. Lorenzo-Lozano, María-Carmen Canalda Campás, Magdalena Juncos Tobarra, María A. Morales-Indiano, Cristian Vírseda Chamorro, Isabel Pastor Murcia, Yolanda Sahuquillo Frías, Laura Altimira Queral, Laura Nuez-Zaragoza, Elisa Adell Ruiz de León, Juan Ruiz Ripa, Alicia Salas Gómez-Pablos, Paloma Cebreiros López, Iria Fernández Uriarte, Amaia Larruzea, Alex López Yepes, María L. Sancho-Rodríguez, Natalia Zamorano Andrés, María C. Pedregosa Díaz, José Sáenz, Luis Esparza del Valle, Clara Baamonde Calzada, María C. García Muñoz, Sara Vera, Marina Martín Torres, Esther Sánchez Fdez-Pacheco, Silvia Vicente Gutiérrez, Luis Jiménez Añón, Laura Pérez Martínez, Alfonso Pons Castillo, Aurelio González Tamayo, Ruth Férriz Vivancos, Jorge Rodríguez-Fraga, Olaia Díaz-Brito, Vicens Aguadero, Vicente García Arévalo, M. G. Arnaldos Carrillo, María González Morales, Mercedes Núñez Gárate, María Ruiz Iruela, Cristina Esteban Torrella, Patricia Vila Pérez, Martí Acevedo Alcaraz, Cristina Blázquez-Manzanera, Alfonso L. Galán Ortega, Amparo |
author_facet | García de Guadiana-Romualdo, Luis Morell-García, Daniel Favaloro, Emmanuel J. Vílchez, Juan A. Bauça, Josep M. Alcaide Martín, María J. Gutiérrez Garcia, Irene de la Hera Cagigal, Patricia Egea-Caparrós, José Manuel Pérez Sanmartín, Sonia Gutiérrez Revilla, José I. Urrechaga, Eloísa Álamo, Jose M. Hernando Holgado, Ana M. Lorenzo-Lozano, María-Carmen Canalda Campás, Magdalena Juncos Tobarra, María A. Morales-Indiano, Cristian Vírseda Chamorro, Isabel Pastor Murcia, Yolanda Sahuquillo Frías, Laura Altimira Queral, Laura Nuez-Zaragoza, Elisa Adell Ruiz de León, Juan Ruiz Ripa, Alicia Salas Gómez-Pablos, Paloma Cebreiros López, Iria Fernández Uriarte, Amaia Larruzea, Alex López Yepes, María L. Sancho-Rodríguez, Natalia Zamorano Andrés, María C. Pedregosa Díaz, José Sáenz, Luis Esparza del Valle, Clara Baamonde Calzada, María C. García Muñoz, Sara Vera, Marina Martín Torres, Esther Sánchez Fdez-Pacheco, Silvia Vicente Gutiérrez, Luis Jiménez Añón, Laura Pérez Martínez, Alfonso Pons Castillo, Aurelio González Tamayo, Ruth Férriz Vivancos, Jorge Rodríguez-Fraga, Olaia Díaz-Brito, Vicens Aguadero, Vicente García Arévalo, M. G. Arnaldos Carrillo, María González Morales, Mercedes Núñez Gárate, María Ruiz Iruela, Cristina Esteban Torrella, Patricia Vila Pérez, Martí Acevedo Alcaraz, Cristina Blázquez-Manzanera, Alfonso L. Galán Ortega, Amparo |
author_sort | García de Guadiana-Romualdo, Luis |
collection | PubMed |
description | Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p < 0.001). D-dimer was an independent predictor of in-hospital mortality, with an adjusted hazard ratio of 1.709. This is the first study in which a harmonization approach was performed to assure comparability of D-dimer levels measured by different assays. Elevated D-dimer levels upon admission were associated with a greater risk of in-hospital mortality among COVID-19 patients, but had limited performance as prognostic test. |
format | Online Article Text |
id | pubmed-8284690 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-82846902021-07-19 Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) García de Guadiana-Romualdo, Luis Morell-García, Daniel Favaloro, Emmanuel J. Vílchez, Juan A. Bauça, Josep M. Alcaide Martín, María J. Gutiérrez Garcia, Irene de la Hera Cagigal, Patricia Egea-Caparrós, José Manuel Pérez Sanmartín, Sonia Gutiérrez Revilla, José I. Urrechaga, Eloísa Álamo, Jose M. Hernando Holgado, Ana M. Lorenzo-Lozano, María-Carmen Canalda Campás, Magdalena Juncos Tobarra, María A. Morales-Indiano, Cristian Vírseda Chamorro, Isabel Pastor Murcia, Yolanda Sahuquillo Frías, Laura Altimira Queral, Laura Nuez-Zaragoza, Elisa Adell Ruiz de León, Juan Ruiz Ripa, Alicia Salas Gómez-Pablos, Paloma Cebreiros López, Iria Fernández Uriarte, Amaia Larruzea, Alex López Yepes, María L. Sancho-Rodríguez, Natalia Zamorano Andrés, María C. Pedregosa Díaz, José Sáenz, Luis Esparza del Valle, Clara Baamonde Calzada, María C. García Muñoz, Sara Vera, Marina Martín Torres, Esther Sánchez Fdez-Pacheco, Silvia Vicente Gutiérrez, Luis Jiménez Añón, Laura Pérez Martínez, Alfonso Pons Castillo, Aurelio González Tamayo, Ruth Férriz Vivancos, Jorge Rodríguez-Fraga, Olaia Díaz-Brito, Vicens Aguadero, Vicente García Arévalo, M. G. Arnaldos Carrillo, María González Morales, Mercedes Núñez Gárate, María Ruiz Iruela, Cristina Esteban Torrella, Patricia Vila Pérez, Martí Acevedo Alcaraz, Cristina Blázquez-Manzanera, Alfonso L. Galán Ortega, Amparo J Thromb Thrombolysis Article Coagulopathy is a key feature of COVID-19 and D-dimer has been reported as a predictor of severity. However, because D-dimer test results vary considerably among assays, resolving harmonization issues is fundamental to translate findings into clinical practice. In this retrospective multicenter study (BIOCOVID study), we aimed to analyze the value of harmonized D-dimer levels upon admission for the prediction of in-hospital mortality in COVID-19 patients. All-cause in-hospital mortality was defined as endpoint. For harmonization of D-dimer levels, we designed a model based on the transformation of method-specific regression lines to a reference regression line. The ability of D-dimer for prediction of death was explored by receiver operating characteristic curves analysis and the association with the endpoint by Cox regression analysis. Study population included 2663 patients. In-hospital mortality rate was 14.3%. Harmonized D-dimer upon admission yielded an area under the curve of 0.66, with an optimal cut-off value of 0.945 mg/L FEU. Patients with harmonized D-dimer ≥ 0.945 mg/L FEU had a higher mortality rate (22.4% vs. 9.2%; p < 0.001). D-dimer was an independent predictor of in-hospital mortality, with an adjusted hazard ratio of 1.709. This is the first study in which a harmonization approach was performed to assure comparability of D-dimer levels measured by different assays. Elevated D-dimer levels upon admission were associated with a greater risk of in-hospital mortality among COVID-19 patients, but had limited performance as prognostic test. Springer US 2021-07-16 2022 /pmc/articles/PMC8284690/ /pubmed/34272635 http://dx.doi.org/10.1007/s11239-021-02527-y Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article García de Guadiana-Romualdo, Luis Morell-García, Daniel Favaloro, Emmanuel J. Vílchez, Juan A. Bauça, Josep M. Alcaide Martín, María J. Gutiérrez Garcia, Irene de la Hera Cagigal, Patricia Egea-Caparrós, José Manuel Pérez Sanmartín, Sonia Gutiérrez Revilla, José I. Urrechaga, Eloísa Álamo, Jose M. Hernando Holgado, Ana M. Lorenzo-Lozano, María-Carmen Canalda Campás, Magdalena Juncos Tobarra, María A. Morales-Indiano, Cristian Vírseda Chamorro, Isabel Pastor Murcia, Yolanda Sahuquillo Frías, Laura Altimira Queral, Laura Nuez-Zaragoza, Elisa Adell Ruiz de León, Juan Ruiz Ripa, Alicia Salas Gómez-Pablos, Paloma Cebreiros López, Iria Fernández Uriarte, Amaia Larruzea, Alex López Yepes, María L. Sancho-Rodríguez, Natalia Zamorano Andrés, María C. Pedregosa Díaz, José Sáenz, Luis Esparza del Valle, Clara Baamonde Calzada, María C. García Muñoz, Sara Vera, Marina Martín Torres, Esther Sánchez Fdez-Pacheco, Silvia Vicente Gutiérrez, Luis Jiménez Añón, Laura Pérez Martínez, Alfonso Pons Castillo, Aurelio González Tamayo, Ruth Férriz Vivancos, Jorge Rodríguez-Fraga, Olaia Díaz-Brito, Vicens Aguadero, Vicente García Arévalo, M. G. Arnaldos Carrillo, María González Morales, Mercedes Núñez Gárate, María Ruiz Iruela, Cristina Esteban Torrella, Patricia Vila Pérez, Martí Acevedo Alcaraz, Cristina Blázquez-Manzanera, Alfonso L. Galán Ortega, Amparo Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title | Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title_full | Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title_fullStr | Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title_full_unstemmed | Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title_short | Harmonized D-dimer levels upon admission for prognosis of COVID-19 severity: Results from a Spanish multicenter registry (BIOCOVID-Spain study) |
title_sort | harmonized d-dimer levels upon admission for prognosis of covid-19 severity: results from a spanish multicenter registry (biocovid-spain study) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284690/ https://www.ncbi.nlm.nih.gov/pubmed/34272635 http://dx.doi.org/10.1007/s11239-021-02527-y |
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