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Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports

RATIONALE: Hypersplenism causes thrombocytopenia, which may lead to the reduction or discontinuation of chemotherapy. Partial splenic embolization (PSE) is an effective treatment for thrombocytopenia associated with hypersplenism. However, there have been no reports of patients with gastric cancer w...

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Autores principales: Nakatsubo, Ryosuke, Yamauchi, Yoshiya, Hiraizumi, Taisho, Naruse, Fumi, Kanda, Ryoya, Suzuki, Yuka, Kakegawa, Tatsuya, Kurosawa, Takashi, Yoshimasu, Yu, Saguchi, Toru, Sofuni, Atsushi, Itoi, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284730/
https://www.ncbi.nlm.nih.gov/pubmed/34260567
http://dx.doi.org/10.1097/MD.0000000000026651
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author Nakatsubo, Ryosuke
Yamauchi, Yoshiya
Hiraizumi, Taisho
Naruse, Fumi
Kanda, Ryoya
Suzuki, Yuka
Kakegawa, Tatsuya
Kurosawa, Takashi
Yoshimasu, Yu
Saguchi, Toru
Sofuni, Atsushi
Itoi, Takao
author_facet Nakatsubo, Ryosuke
Yamauchi, Yoshiya
Hiraizumi, Taisho
Naruse, Fumi
Kanda, Ryoya
Suzuki, Yuka
Kakegawa, Tatsuya
Kurosawa, Takashi
Yoshimasu, Yu
Saguchi, Toru
Sofuni, Atsushi
Itoi, Takao
author_sort Nakatsubo, Ryosuke
collection PubMed
description RATIONALE: Hypersplenism causes thrombocytopenia, which may lead to the reduction or discontinuation of chemotherapy. Partial splenic embolization (PSE) is an effective treatment for thrombocytopenia associated with hypersplenism. However, there have been no reports of patients with gastric cancer who have resumed and continued chemotherapy after PSE for splenic hypersplenism associated with tumor infiltration. Here, we report two cases in which we performed PSE for hypersplenism associated with gastric cancer that had invaded the splenic vein. Chemotherapy was continued in both cases. PATIENT CONCERNS: Both patients developed thrombocytopenia with splenomegaly due to advanced gastric cancer that required discontinuation of chemotherapy. DIAGNOSIS: Upper gastrointestinal endoscopy and computed tomography showed advanced gastric cancer with invasion of the splenic vein and splenomegaly. Both patients developed thrombocytopenia. INTERVENTIONS: Patients were treated with PSE. OUTCOMES: PSE produced an increase in thrombocyte count, and chemotherapy could be resumed. LESSONS: PSE seems to be a useful treatment for thrombocytopenia with splenomegaly associated with advanced gastric cancer and may allow continuation of chemotherapy.
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spelling pubmed-82847302021-07-19 Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports Nakatsubo, Ryosuke Yamauchi, Yoshiya Hiraizumi, Taisho Naruse, Fumi Kanda, Ryoya Suzuki, Yuka Kakegawa, Tatsuya Kurosawa, Takashi Yoshimasu, Yu Saguchi, Toru Sofuni, Atsushi Itoi, Takao Medicine (Baltimore) 4500 RATIONALE: Hypersplenism causes thrombocytopenia, which may lead to the reduction or discontinuation of chemotherapy. Partial splenic embolization (PSE) is an effective treatment for thrombocytopenia associated with hypersplenism. However, there have been no reports of patients with gastric cancer who have resumed and continued chemotherapy after PSE for splenic hypersplenism associated with tumor infiltration. Here, we report two cases in which we performed PSE for hypersplenism associated with gastric cancer that had invaded the splenic vein. Chemotherapy was continued in both cases. PATIENT CONCERNS: Both patients developed thrombocytopenia with splenomegaly due to advanced gastric cancer that required discontinuation of chemotherapy. DIAGNOSIS: Upper gastrointestinal endoscopy and computed tomography showed advanced gastric cancer with invasion of the splenic vein and splenomegaly. Both patients developed thrombocytopenia. INTERVENTIONS: Patients were treated with PSE. OUTCOMES: PSE produced an increase in thrombocyte count, and chemotherapy could be resumed. LESSONS: PSE seems to be a useful treatment for thrombocytopenia with splenomegaly associated with advanced gastric cancer and may allow continuation of chemotherapy. Lippincott Williams & Wilkins 2021-07-16 /pmc/articles/PMC8284730/ /pubmed/34260567 http://dx.doi.org/10.1097/MD.0000000000026651 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 4500
Nakatsubo, Ryosuke
Yamauchi, Yoshiya
Hiraizumi, Taisho
Naruse, Fumi
Kanda, Ryoya
Suzuki, Yuka
Kakegawa, Tatsuya
Kurosawa, Takashi
Yoshimasu, Yu
Saguchi, Toru
Sofuni, Atsushi
Itoi, Takao
Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title_full Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title_fullStr Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title_full_unstemmed Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title_short Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: Case reports
title_sort successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein: case reports
topic 4500
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284730/
https://www.ncbi.nlm.nih.gov/pubmed/34260567
http://dx.doi.org/10.1097/MD.0000000000026651
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