Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis

BACKGROUND: Antidepressant drugs are mainly used to treat depression clinically. ABCB1 affects the P-glycoprotein activity and changes the amount of drugs in the blood tissue barrier that can be squeezed back into the blood, thus affecting the efficacy of antidepressants. In this present study, Meta...

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Autores principales: Zheng, Xiaoying, Fu, Zejuan, Chen, Xiaomei, Wang, Mingxia, Zhu, Rixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
5000
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284742/
https://www.ncbi.nlm.nih.gov/pubmed/34260525
http://dx.doi.org/10.1097/MD.0000000000026411
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author Zheng, Xiaoying
Fu, Zejuan
Chen, Xiaomei
Wang, Mingxia
Zhu, Rixia
author_facet Zheng, Xiaoying
Fu, Zejuan
Chen, Xiaomei
Wang, Mingxia
Zhu, Rixia
author_sort Zheng, Xiaoying
collection PubMed
description BACKGROUND: Antidepressant drugs are mainly used to treat depression clinically. ABCB1 affects the P-glycoprotein activity and changes the amount of drugs in the blood tissue barrier that can be squeezed back into the blood, thus affecting the efficacy of antidepressants. In this present study, Meta-analysis was performed to further investigate the influences of ABCB1 gene polymorphism on antidepressant response. METHODS: Relevant literatures were searched from the PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, China Biology Medicine disc, and Wan Fang databases up to May 2021 without any language restrictions. STATA 16.0 software was applied for this meta-analysis. Odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This meta-analysis will summarize the effects of ABCB1 gene polymorphism on antidepressant response.
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spelling pubmed-82847422021-07-19 Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis Zheng, Xiaoying Fu, Zejuan Chen, Xiaomei Wang, Mingxia Zhu, Rixia Medicine (Baltimore) 5000 BACKGROUND: Antidepressant drugs are mainly used to treat depression clinically. ABCB1 affects the P-glycoprotein activity and changes the amount of drugs in the blood tissue barrier that can be squeezed back into the blood, thus affecting the efficacy of antidepressants. In this present study, Meta-analysis was performed to further investigate the influences of ABCB1 gene polymorphism on antidepressant response. METHODS: Relevant literatures were searched from the PubMed, EMBASE, Web of Science, Chinese National Knowledge Infrastructure, Chinese Science and Technique Journals Database, China Biology Medicine disc, and Wan Fang databases up to May 2021 without any language restrictions. STATA 16.0 software was applied for this meta-analysis. Odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated. RESULTS: The results of this meta-analysis will be submitted to a peer-reviewed journal for publication. CONCLUSION: This meta-analysis will summarize the effects of ABCB1 gene polymorphism on antidepressant response. Lippincott Williams & Wilkins 2021-07-16 /pmc/articles/PMC8284742/ /pubmed/34260525 http://dx.doi.org/10.1097/MD.0000000000026411 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle 5000
Zheng, Xiaoying
Fu, Zejuan
Chen, Xiaomei
Wang, Mingxia
Zhu, Rixia
Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title_full Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title_fullStr Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title_full_unstemmed Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title_short Effects of ABCB1 gene polymorphism on the efficacy of antidepressant drugs: A protocol for systematic review and meta-analysis
title_sort effects of abcb1 gene polymorphism on the efficacy of antidepressant drugs: a protocol for systematic review and meta-analysis
topic 5000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284742/
https://www.ncbi.nlm.nih.gov/pubmed/34260525
http://dx.doi.org/10.1097/MD.0000000000026411
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