Current perspectives of limbal‐derived stem cells and its application in ocular surface regeneration and limbal stem cell transplantation

Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanti...

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Detalles Bibliográficos
Autores principales: Singh, Vivek, Tiwari, Anil, Kethiri, Abhinav Reddy, Sangwan, Virender Singh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284782/
https://www.ncbi.nlm.nih.gov/pubmed/33951336
http://dx.doi.org/10.1002/sctm.20-0408
Descripción
Sumario:Limbal stem cells are involved in replenishing and maintaining the epithelium of the cornea. Damage to the limbus due to chemical/physical injury, infections, or genetic disorders leads to limbal stem cell deficiency (LSCD) with partial or total vision loss. Presently, LSCD is treated by transplanting limbal stem cells from the healthy eye of the recipient, living‐related, or cadaveric donors. This review discusses limbal‐derived stem cells, the importance of extracellular matrix in stem cell niche maintenance, the historical perspective of treating LSCD, including related advantages and limitations, and our experience of limbal stem cell transplantation over the decades.

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