Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques

There is an urgent need for effective therapeutic interventions against SARS-CoV-2, including new variants that continue to arise. Neutralizing monoclonal antibodies have shown promise in clinical studies. We investigated the therapeutic efficacy of a combination of two potent monoclonal antibodies,...

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Detalles Bibliográficos
Autores principales: Van Rompay, Koen K. A., Olstad, Katherine J., Sammak, Rebecca L., Dutra, Joseph, Watanabe, Jennifer K., Usachenko, Jodie L., Immareddy, Ramya, Verma, Anil, Shaan Lakshmanappa, Yashavanth, Schmidt, Brian A., Roh, Jamin W., Elizaldi, Sonny R., Allen, A. Mark, Muecksch, Frauke, Lorenzi, Julio C. C., Lockwood, Sarah, Pollard, Rachel E., Yee, JoAnn L., Nham, Peter B., Ardeshir, Amir, Deere, Jesse D., Patterson, Jean, Dang, Que, Hatziioannou, Theodora, Bieniasz, Paul D., Iyer, Smita S., Hartigan-O’Connor, Dennis J., Nussenzweig, Michel C., Reader, J. Rachel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284825/
https://www.ncbi.nlm.nih.gov/pubmed/34228761
http://dx.doi.org/10.1371/journal.ppat.1009688

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