Synaptotagmin-7–mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants

Synaptotagmin-7 (Syt7) plays direct or redundant Ca(2+) sensor roles in multiple forms of vesicle exocytosis in synapses. Here, we show that Syt7 is a redundant Ca(2+) sensor with Syt1/Doc2 to drive spontaneous glutamate release, which functions uniquely to activate the postsynaptic GluN2B-containin...

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Detalles Bibliográficos
Autores principales: Wang, Qiu-Wen, Wang, Ying-Han, Wang, Bing, Chen, Yun, Lu, Si-Yao, Yao, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284830/
https://www.ncbi.nlm.nih.gov/pubmed/34228711
http://dx.doi.org/10.1371/journal.pbio.3001323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284830/
https://www.ncbi.nlm.nih.gov/pubmed/34228711
http://dx.doi.org/10.1371/journal.pbio.3001323

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