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Plasmid hypermutation using a targeted artificial DNA replisome
Extensive exploration of a protein’s sequence space for improved or new molecular functions requires in vivo evolution with large populations. But disentangling the evolution of a target protein from the rest of the proteome is challenging. Here, we designed a protein complex of a targeted artificia...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Association for the Advancement of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284885/ https://www.ncbi.nlm.nih.gov/pubmed/34272238 http://dx.doi.org/10.1126/sciadv.abg8712 |