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Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Association for the Advancement of Science
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284894/ https://www.ncbi.nlm.nih.gov/pubmed/34272249 http://dx.doi.org/10.1126/sciadv.abg2286 |
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author | Ren, Guangpeng Zhang, Xu Li, Ying Ridout, Kate Serrano-Serrano, Martha L. Yang, Yongzhi Liu, Ai Ravikanth, Gudasalamani Nawaz, Muhammad Ali Mumtaz, Abdul Samad Salamin, Nicolas Fumagalli, Luca |
author_facet | Ren, Guangpeng Zhang, Xu Li, Ying Ridout, Kate Serrano-Serrano, Martha L. Yang, Yongzhi Liu, Ai Ravikanth, Gudasalamani Nawaz, Muhammad Ali Mumtaz, Abdul Samad Salamin, Nicolas Fumagalli, Luca |
author_sort | Ren, Guangpeng |
collection | PubMed |
description | Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China. We identified candidate genes associated with traits differentiating hemp and drug cultivars, including branching pattern and cellulose/lignin biosynthesis. We also found evidence for loss of function of genes involved in the synthesis of the two major biochemically competing cannabinoids during selection for increased fiber production or psychoactive properties. Our results provide a unique global view of the domestication of C. sativa and offer valuable genomic resources for ongoing functional and molecular breeding research. |
format | Online Article Text |
id | pubmed-8284894 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-82848942021-08-02 Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa Ren, Guangpeng Zhang, Xu Li, Ying Ridout, Kate Serrano-Serrano, Martha L. Yang, Yongzhi Liu, Ai Ravikanth, Gudasalamani Nawaz, Muhammad Ali Mumtaz, Abdul Samad Salamin, Nicolas Fumagalli, Luca Sci Adv Research Articles Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp and drug cultivars diverged from an ancestral gene pool currently represented by feral plants and landraces in China. We identified candidate genes associated with traits differentiating hemp and drug cultivars, including branching pattern and cellulose/lignin biosynthesis. We also found evidence for loss of function of genes involved in the synthesis of the two major biochemically competing cannabinoids during selection for increased fiber production or psychoactive properties. Our results provide a unique global view of the domestication of C. sativa and offer valuable genomic resources for ongoing functional and molecular breeding research. American Association for the Advancement of Science 2021-07-16 /pmc/articles/PMC8284894/ /pubmed/34272249 http://dx.doi.org/10.1126/sciadv.abg2286 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Ren, Guangpeng Zhang, Xu Li, Ying Ridout, Kate Serrano-Serrano, Martha L. Yang, Yongzhi Liu, Ai Ravikanth, Gudasalamani Nawaz, Muhammad Ali Mumtaz, Abdul Samad Salamin, Nicolas Fumagalli, Luca Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title | Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title_full | Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title_fullStr | Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title_full_unstemmed | Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title_short | Large-scale whole-genome resequencing unravels the domestication history of Cannabis sativa |
title_sort | large-scale whole-genome resequencing unravels the domestication history of cannabis sativa |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284894/ https://www.ncbi.nlm.nih.gov/pubmed/34272249 http://dx.doi.org/10.1126/sciadv.abg2286 |
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