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Carbimazole induced rhabdomyolysis

SUMMARY: Carbimazole is a commonly used antithyroid drug (ATD), which is associated with several well-established side effects. However, Carbimazole-induced rhabdomyolysis is rarely reported in the literature. We report a 27-year-old male who presented with upper limb myalgia and significantly raise...

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Autores principales: O’Donnell, Niamh, McCarthy, Aisling, Thong, Ken
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284947/
https://www.ncbi.nlm.nih.gov/pubmed/34196275
http://dx.doi.org/10.1530/EDM-21-0006
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author O’Donnell, Niamh
McCarthy, Aisling
Thong, Ken
author_facet O’Donnell, Niamh
McCarthy, Aisling
Thong, Ken
author_sort O’Donnell, Niamh
collection PubMed
description SUMMARY: Carbimazole is a commonly used antithyroid drug (ATD), which is associated with several well-established side effects. However, Carbimazole-induced rhabdomyolysis is rarely reported in the literature. We report a 27-year-old male who presented with upper limb myalgia and significantly raised creatine kinase elevation, 1-month post commencement of Carbimazole for Graves’ disease. Carbimazole was ceased with subsequent clinical and biochemical improvement. Though the pathophysiology remains unclear, we hope to raise awareness regarding this rare adverse effect with a view to promote early recognition and prompt discontinuation of the offending medication caused by a commonly used medication in endocrinology. LEARNING POINTS: Musculoskeletal complaints can relate to unidentified and untreated hyperthyroidism. However one must be mindful that the treatment for these disorders can too induce myopathies. ATD-induced myopathy should be considered when there is a temporal relationship between introduction of ATDs and the onset of symptoms. If ATD-induced myopathy is being considered, other causes of myopathy should still be outruled. Prompt discontinuation of potentially offending medications may provide resolution of symptoms and avoid significant consequences.
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spelling pubmed-82849472021-07-20 Carbimazole induced rhabdomyolysis O’Donnell, Niamh McCarthy, Aisling Thong, Ken Endocrinol Diabetes Metab Case Rep Unusual Effects of Medical Treatment SUMMARY: Carbimazole is a commonly used antithyroid drug (ATD), which is associated with several well-established side effects. However, Carbimazole-induced rhabdomyolysis is rarely reported in the literature. We report a 27-year-old male who presented with upper limb myalgia and significantly raised creatine kinase elevation, 1-month post commencement of Carbimazole for Graves’ disease. Carbimazole was ceased with subsequent clinical and biochemical improvement. Though the pathophysiology remains unclear, we hope to raise awareness regarding this rare adverse effect with a view to promote early recognition and prompt discontinuation of the offending medication caused by a commonly used medication in endocrinology. LEARNING POINTS: Musculoskeletal complaints can relate to unidentified and untreated hyperthyroidism. However one must be mindful that the treatment for these disorders can too induce myopathies. ATD-induced myopathy should be considered when there is a temporal relationship between introduction of ATDs and the onset of symptoms. If ATD-induced myopathy is being considered, other causes of myopathy should still be outruled. Prompt discontinuation of potentially offending medications may provide resolution of symptoms and avoid significant consequences. Bioscientifica Ltd 2021-06-07 /pmc/articles/PMC8284947/ /pubmed/34196275 http://dx.doi.org/10.1530/EDM-21-0006 Text en © The authors https://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Unusual Effects of Medical Treatment
O’Donnell, Niamh
McCarthy, Aisling
Thong, Ken
Carbimazole induced rhabdomyolysis
title Carbimazole induced rhabdomyolysis
title_full Carbimazole induced rhabdomyolysis
title_fullStr Carbimazole induced rhabdomyolysis
title_full_unstemmed Carbimazole induced rhabdomyolysis
title_short Carbimazole induced rhabdomyolysis
title_sort carbimazole induced rhabdomyolysis
topic Unusual Effects of Medical Treatment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284947/
https://www.ncbi.nlm.nih.gov/pubmed/34196275
http://dx.doi.org/10.1530/EDM-21-0006
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