Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidity

Coronaviruses cause severe human viral diseases including SARS, MERS and COVID-19. Most recently SARS-CoV-2 virus (causing COVID-19) has led to a pandemic with no successful therapeutics. The SARS-CoV-2 infection relies on trimeric spike (S) proteins to facilitate virus entry into host cells by bind...

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Detalles Bibliográficos
Autores principales: Dong, Jianbo, Huang, Betty, Jia, Zhejun, Wang, Bo, Gallolu Kankanamalage, Sachith, Titong, Allison, Liu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284970/
https://www.ncbi.nlm.nih.gov/pubmed/32403995
http://dx.doi.org/10.1080/22221751.2020.1768806

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