Cargando…

An epigenetic switch regulates the ontogeny of AXL-positive/EGFR-TKi-resistant cells by modulating miR-335 expression

Despite current advancements in research and therapeutics, lung cancer remains the leading cause of cancer-related mortality worldwide. This is mainly due to the resistance that patients develop against chemotherapeutic agents over the course of treatment. In the context of non-small cell lung cance...

Descripción completa

Detalles Bibliográficos
Autores principales:	Safaric Tepes, Polona, Pal, Debjani, Lindsted, Trine, Ibarra, Ingrid, Lujambio, Amaia, Jimenez Sabinina, Vilma, Senturk, Serif, Miller, Madison, Korimerla, Navya, Huang, Jiahao, Glassman, Lawrence, Lee, Paul, Zeltsman, David, Hyman, Kevin, Esposito, Michael, Hannon, Gregory J, Sordella, Raffaella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2021
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285107/ https://www.ncbi.nlm.nih.gov/pubmed/34254585 http://dx.doi.org/10.7554/eLife.66109

Ejemplares similares

Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny
por: Malawista, Anna, et al.
Publicado: (2016)

Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization
por: Senturk, Serif, et al.
Publicado: (2017)

AXL Knock-Out in SNU475 Hepatocellular Carcinoma Cells Provides Evidence for Lethal Effect Associated with G2 Arrest and Polyploidization
por: Batur, Tugce, et al.
Publicado: (2021)

Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
por: Shirole, Nitin H, et al.
Publicado: (2017)

TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
por: Shirole, Nitin H, et al.
Publicado: (2016)

Intermediate oncologic outcomes after uniportal video-assisted thoracoscopic thymectomy for early-stage thymoma
por: Pupovac, Stevan S., et al.
Publicado: (2020)

AUY922 Effectively Overcomes MET- and AXL-Mediated Resistance to EGFR-TKI in Lung Cancer Cells
por: Choi, Yun Jung, et al.
Publicado: (2015)

SAT-335 Resistin Induces Epithelial to Mesenchymal Transition (EMT) in Breast Cancer Cells through Activation of AXL Tyrosine Kinase Receptor
por: Weber, Daniel, et al.
Publicado: (2019)

AXL degradation in combination with EGFR-TKI can delay and overcome acquired resistance in human non-small cell lung cancer cells
por: Kim, Donghwa, et al.
Publicado: (2019)

Anexelekto (AXL) Increases Resistance to EGFR-TKI and Activation of AKT and ERK1/2 in Non-Small Cell Lung Cancer Cells
por: Tian, Yaqiong, et al.
Publicado: (2016)

Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
por: Sun, Qi, et al.
Publicado: (2022)

Health Tract No. 335: Eyesight
Publicado: (1868)

Giving AXL the axe: targeting AXL in human malignancy
por: Gay, Carl M, et al.
Publicado: (2017)

Genomics and Functional Genomics of Malignant Pleural Mesothelioma
por: Cakiroglu, Ece, et al.
Publicado: (2020)

Characterization of miR-335-5p and miR-335-3p in human osteoarthritic tissues
por: Wilson, Thomas G., et al.
Publicado: (2023)

TKI safety
por: Hjorth-Hansen, Henrik
Publicado: (2019)

Ontogeny and phylogeny /
por: Gould, Stephen Jay
Publicado: (1977)

Targeting AXL in NSCLC
por: Zaman, Aubhishek, et al.
Publicado: (2021)

Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells
por: Toktay, Yagmur, et al.
Publicado: (2022)

Plants, Prayers and Plague: Wellcome MS. 335
por: Laforet, Alice
Publicado: (2015)

Functions and Targets of miR-335 in Cancer
por: Ye, Lingling, et al.
Publicado: (2021)

The Bright and the Dark Side of TGF-β Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications
por: Gungor, Medine Zeynep, et al.
Publicado: (2022)

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels
por: Fritz, Helena K., et al.
Publicado: (2015)

Immune Evasion Mechanism and AXL
por: Son, Hye-Youn, et al.
Publicado: (2021)

Patent Spring Washer Axles
Publicado: (1878)

Ontogeny of bonding-attachment
Publicado: (1984)

Ontogeny of Myeloid Cells
por: De Kleer, Ismé, et al.
Publicado: (2014)

The ontogeny of learned inhibition
por: Meyer, Heidi C., et al.
Publicado: (2014)

Phylogeny and Ontogeny of Erythropoiesis
por: Nunomura, Wataru, et al.
Publicado: (2015)

The Ontogeny of Monocyte Subsets
por: Wolf, Anja A., et al.
Publicado: (2019)

Craniofacial ontogeny in Tylosaurinae
por: Zietlow, Amelia R.
Publicado: (2020)

Ontogeny of collective behaviour
por: Muratore, Isabella Benter, et al.
Publicado: (2023)

Topology Optimization and Multiobjective Optimization for Drive Axle Housing of a Rear Axle Drive Truck
por: Zheng, Bin, et al.
Publicado: (2022)

Technical Report Abstracts: TR-335 to TR-364
Publicado: (1993)

335 Sources of Sound Exposure in Pediatric Critical Care
por: Kalvas, Laura Beth, et al.
Publicado: (2023)

Next-Generation Liver Medicine Using Organoid Models
por: Akbari, Soheil, et al.
Publicado: (2019)

Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKI-Resistant Lung Cancer
por: Wang, Tong-Hong, et al.
Publicado: (2020)

The TKI Era in Chronic Leukemias
por: De Novellis, Danilo, et al.
Publicado: (2021)

AXL is an oncotarget in human colorectal cancer
por: Martinelli, Erika, et al.
Publicado: (2015)

Analysis of the Vehicle Chassis Axle Fractures
por: Decker, Živilė, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_c5skklsb531dec173ponrm20ss