Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), part...

Descripción completa

Detalles Bibliográficos
Autores principales: Otieno, Steve Biko, Altahan, Alaa, Kaweeta, Fnu, Karri, Saradasri, Alnoor, Fnu, Johnson, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285198/
https://www.ncbi.nlm.nih.gov/pubmed/34306774
http://dx.doi.org/10.1155/2021/6619177
_version_ 1783723509600485376
author Otieno, Steve Biko
Altahan, Alaa
Kaweeta, Fnu
Karri, Saradasri
Alnoor, Fnu
Johnson, Robert
author_facet Otieno, Steve Biko
Altahan, Alaa
Kaweeta, Fnu
Karri, Saradasri
Alnoor, Fnu
Johnson, Robert
author_sort Otieno, Steve Biko
collection PubMed
description Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH.
format Online
Article
Text
id pubmed-8285198
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-82851982021-07-22 Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria Otieno, Steve Biko Altahan, Alaa Kaweeta, Fnu Karri, Saradasri Alnoor, Fnu Johnson, Robert Case Rep Hematol Case Report Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), has been demonstrated to be able to activate complement, making patients with deficiency in negative complement regulation, such as paroxysmal nocturnal hemoglobinuria (PNH), particularly vulnerable to complement-mediated cell damage. We report a case of a patient who presented with fatigue, facial swelling, and upper respiratory infection (URI) symptoms and was found to have COVID-19 with laboratory tests showing severe hemolysis and pancytopenia secondary to PNH. Hindawi 2021-07-13 /pmc/articles/PMC8285198/ /pubmed/34306774 http://dx.doi.org/10.1155/2021/6619177 Text en Copyright © 2021 Steve Biko Otieno et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Otieno, Steve Biko
Altahan, Alaa
Kaweeta, Fnu
Karri, Saradasri
Alnoor, Fnu
Johnson, Robert
Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title_full Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title_fullStr Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title_full_unstemmed Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title_short Severe Hemolysis in a COVID-19 Patient with Paroxysmal Nocturnal Hemoglobinuria
title_sort severe hemolysis in a covid-19 patient with paroxysmal nocturnal hemoglobinuria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285198/
https://www.ncbi.nlm.nih.gov/pubmed/34306774
http://dx.doi.org/10.1155/2021/6619177
work_keys_str_mv AT otienostevebiko severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria
AT altahanalaa severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria
AT kaweetafnu severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria
AT karrisaradasri severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria
AT alnoorfnu severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria
AT johnsonrobert severehemolysisinacovid19patientwithparoxysmalnocturnalhemoglobinuria

Ejemplares similares