Liver injury in COVID-19 and IL-6 trans-signaling-induced endotheliopathy

BACKGROUND AND AIMS: COVID-19 is associated with liver injury and elevated interleukin-6 (IL-6). We hypothesized that IL-6 trans-signaling in liver sinusoidal endothelial cells (LSECs) leads to endotheliopathy (a proinflammatory and procoagulant state) and liver injury in COVID-19. METHODS: Coagulop...

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Detalles Bibliográficos
Autores principales: McConnell, Matthew J., Kawaguchi, Nao, Kondo, Reiichiro, Sonzogni, Aurelio, Licini, Lisa, Valle, Clarissa, Bonaffini, Pietro A., Sironi, Sandro, Alessio, Maria Grazia, Previtali, Giulia, Seghezzi, Michela, Zhang, Xuchen, Lee, Alfred I., Pine, Alexander B., Chun, Hyung J., Zhang, Xinbo, Fernandez-Hernando, Carlos, Qing, Hua, Wang, Andrew, Price, Christina, Sun, Zhaoli, Utsumi, Teruo, Hwa, John, Strazzabosco, Mario, Iwakiri, Yasuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Association for the Study of the Liver. Published by Elsevier B.V. 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285256/
https://www.ncbi.nlm.nih.gov/pubmed/33991637
http://dx.doi.org/10.1016/j.jhep.2021.04.050

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