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PLEKHO2 inhibits TNFα-induced cell death by suppressing RIPK1 activation

Receptor interaction protein kinase 1 (RIPK1) plays a diverse role in tumor necrosis factor α (TNFα) signalings. The ubiquitination of RIPK1 is essential for NF-κB activation, whereas its kinase activity promotes apoptosis and necroptosis. However, the mechanisms underlying have not been fully illum...

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Detalles Bibliográficos
Autores principales:	Zhou, Chenchen, Zhang, Xueli, Yang, Cuiping, He, Yuan, Zhang, Luo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285381/ https://www.ncbi.nlm.nih.gov/pubmed/34272357 http://dx.doi.org/10.1038/s41419-021-04001-2

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