Cytosine and adenine deaminase base-editors induce broad and nonspecific changes in gene expression and splicing

Cytosine or adenine base editors (CBEs or ABEs) hold great promise in therapeutic applications because they enable the precise conversion of targeted base changes without generating of double-strand breaks. However, both CBEs and ABEs induce substantial off-target DNA editing, and extensive off-targ...

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Detalles Bibliográficos
Autores principales: Fan, Jiao, Ding, Yige, Ren, Chao, Song, Ziguo, Yuan, Jie, Chen, Qiuzhen, Du, Chenchen, Li, Chao, Wang, Xiaolong, Shu, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285404/
https://www.ncbi.nlm.nih.gov/pubmed/34272468
http://dx.doi.org/10.1038/s42003-021-02406-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285404/
https://www.ncbi.nlm.nih.gov/pubmed/34272468
http://dx.doi.org/10.1038/s42003-021-02406-5

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