Cargando…

Cytosine and adenine deaminase base-editors induce broad and nonspecific changes in gene expression and splicing

Cytosine or adenine base editors (CBEs or ABEs) hold great promise in therapeutic applications because they enable the precise conversion of targeted base changes without generating of double-strand breaks. However, both CBEs and ABEs induce substantial off-target DNA editing, and extensive off-targ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fan, Jiao, Ding, Yige, Ren, Chao, Song, Ziguo, Yuan, Jie, Chen, Qiuzhen, Du, Chenchen, Li, Chao, Wang, Xiaolong, Shu, Wenjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285404/ https://www.ncbi.nlm.nih.gov/pubmed/34272468 http://dx.doi.org/10.1038/s42003-021-02406-5

Ejemplares similares

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing
por: Grünewald, Julian, et al.
Publicado: (2020)

Targeting fidelity of adenine and cytosine base editors in mouse embryos
por: Lee, Hye Kyung, et al.
Publicado: (2018)

Examination of the Cell Cycle Dependence of Cytosine and Adenine Base Editors
por: Burnett, Cameron A., et al.
Publicado: (2022)

TadA orthologs enable both cytosine and adenine editing of base editors
por: Zhang, Shuqian, et al.
Publicado: (2023)

Cytosine base editor 4 but not adenine base editor generates off-target mutations in mouse embryos
por: Lee, Hye Kyung, et al.
Publicado: (2020)

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity
por: Neugebauer, Monica E., et al.
Publicado: (2022)

Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors
por: Chen, Fangbing, et al.
Publicado: (2022)

BEAR reveals that increased fidelity variants can successfully reduce the mismatch tolerance of adenine but not cytosine base editors
por: Tálas, András, et al.
Publicado: (2021)

Improved Dual Base Editor Systems (iACBEs) for Simultaneous Conversion of Adenine and Cytosine in the Bacterium Escherichia coli
por: Shelake, Rahul Mahadev, et al.
Publicado: (2023)

Programmable adenine deamination in bacteria using a Cas9–adenine-deaminase fusion
por: Zhang, Ya, et al.
Publicado: (2020)

AID/APOBEC cytosine deaminase induces genome-wide kataegis
por: Lada, Artem G, et al.
Publicado: (2012)

Elimination of Cas9-dependent off-targeting of adenine base editor by using TALE to separately guide deaminase to target sites
por: Liu, Yang, et al.
Publicado: (2022)

Global analysis of cytosine and adenine DNA modifications across the tree of life
por: Varma, Sreejith Jayasree, et al.
Publicado: (2022)

AID/APOBEC deaminases disfavor modified cytosines implicated in DNA demethylation
por: Nabel, Christopher S., et al.
Publicado: (2012)

Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells
por: Mesa-Pereira, Beatriz, et al.
Publicado: (2015)

Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers
por: Ding, Yuedi, et al.
Publicado: (2020)

Biochemical Characterization of Kluyveromyces lactis Adenine Deaminase and Guanine Deaminase and Their Potential Application in Lowering Purine Content in Beer
por: Mahor, Durga, et al.
Publicado: (2018)

Surface-Enhanced Hyper-Raman Spectra of Adenine, Guanine, Cytosine, Thymine, and Uracil
por: Madzharova, Fani, et al.
Publicado: (2016)

Adenine·cytosine substitutions are an alternative pathway of compensatory mutation in angiosperm ITS2
por: Zhang, Xinwan, et al.
Publicado: (2020)

Efficacy of gene therapy-delivered cytosine deaminase is determined by enzymatic activity but not expression
por: Dubois, L, et al.
Publicado: (2007)

Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas
por: Zhang, Yue-Lin, et al.
Publicado: (2020)

Graphene Oxide Nanoribbons in Chitosan for Simultaneous Electrochemical Detection of Guanine, Adenine, Thymine and Cytosine
por: Zhou, Jiayun, et al.
Publicado: (2020)

DNA methylation on C5-Cytosine and N6-Adenine in the Bursaphelenchus xylophilus genome
por: Liu, Zhenkai, et al.
Publicado: (2023)

Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs
por: Vande Voorde, Johan, et al.
Publicado: (2015)

Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B
por: Shi, Ke, et al.
Publicado: (2017)

The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS
por: Niocel, Mathilde, et al.
Publicado: (2019)

Engineering the Active Site Lid Dynamics to Improve the Catalytic Efficiency of Yeast Cytosine Deaminase
por: Deng, Hanzhong, et al.
Publicado: (2023)

Simplified adenine base editors improve adenine base editing efficiency in rice
por: Hua, Kai, et al.
Publicado: (2019)

Small-molecule compounds boost genome-editing efficiency of cytosine base editor
por: Zhao, Tianyuan, et al.
Publicado: (2021)

The androgen receptor cytosine-adenine-guanine repeat length contributes to the development of epithelial ovarian cancer
por: Meng, Xiangrui, et al.
Publicado: (2015)

Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts
por: Liu, J, et al.
Publicado: (2007)

Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
por: Sung Park, Jin, et al.
Publicado: (2013)

Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B
por: Akre, Monica K., et al.
Publicado: (2016)

APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A
por: Wong, Lai, et al.
Publicado: (2020)

Biochemical behavior of N-oxidized cytosine and adenine bases in DNA polymerase-mediated primer extension reactions
por: Tsunoda, Hirosuke, et al.
Publicado: (2011)

Development of a universal antibiotic resistance screening reporter for improving efficiency of cytosine and adenine base editing
por: Ma, Lixia, et al.
Publicado: (2022)

Adenoviral-Mediated Imaging of Gene Transfer Using a Somatostatin Receptor-Cytosine Deaminase Fusion Protein
por: Lears, Kimberly A., et al.
Publicado: (2015)

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer
por: Law, Emily K., et al.
Publicado: (2016)

Human activation-induced deaminase lacks strong replicative strand bias or preference for cytosines in hairpin loops
por: Sakhtemani, Ramin, et al.
Publicado: (2022)

Structural basis of sequence-specific cytosine deamination by double-stranded DNA deaminase toxin DddA
por: Yin, Lulu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_elet0s03ngnj6q4cv6ad4rt2l6