Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage

Although homologous recombination (HR) is indicated as a high-fidelity repair mechanism, break-induced replication (BIR), a subtype of HR, is a mutagenic mechanism that leads to chromosome rearrangements. It remains poorly understood how cells suppress mutagenic BIR. Trapping of Topoisomerase 1 by c...

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Detalles Bibliográficos
Autores principales: Wu, Xiao, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285526/
https://www.ncbi.nlm.nih.gov/pubmed/34272385
http://dx.doi.org/10.1038/s41467-021-24665-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285526/
https://www.ncbi.nlm.nih.gov/pubmed/34272385
http://dx.doi.org/10.1038/s41467-021-24665-w

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