Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan

BACKGROUND: Mycobacterium abscessus frequently causes severe infections, yet its pathophysiological features and treatment regimens have not been established. CASE REPORT: We present five cases of severe pneumonia due to Mycobacterium abscessus infection in Japan. All cases were diabetic patients, w...

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Autores principales: Takano, Kazuki, Shimada, Daishi, Kashiwagura, Shota, Kamioka, Yasuhiro, Hariu, Maya, Watanabe, Yuji, Seki, Masafumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Case Series
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285566/
https://www.ncbi.nlm.nih.gov/pubmed/34285595
http://dx.doi.org/10.2147/IMCRJ.S321969
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author Takano, Kazuki
Shimada, Daishi
Kashiwagura, Shota
Kamioka, Yasuhiro
Hariu, Maya
Watanabe, Yuji
Seki, Masafumi
author_facet Takano, Kazuki
Shimada, Daishi
Kashiwagura, Shota
Kamioka, Yasuhiro
Hariu, Maya
Watanabe, Yuji
Seki, Masafumi
author_sort Takano, Kazuki
collection PubMed
description BACKGROUND: Mycobacterium abscessus frequently causes severe infections, yet its pathophysiological features and treatment regimens have not been established. CASE REPORT: We present five cases of severe pneumonia due to Mycobacterium abscessus infection in Japan. All cases were diabetic patients, with possible acceleration to pneumonia due to co-infection with other microorganisms. However, following a short period of hospitalization and combination therapy with intravenous imipenem/cilastatin and amikacin, all the cases were successfully treated as outpatients with oral clarithromycin and sitafloxacin. CONCLUSION: M. abscessus infections can become severe in the presence of diabetes mellitus and co-infection with other chronic infectious organisms. Sitafloxacin might be a key drug in the treatment of M. abscessus infection in future.
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spelling pubmed-82855662021-07-19 Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan Takano, Kazuki Shimada, Daishi Kashiwagura, Shota Kamioka, Yasuhiro Hariu, Maya Watanabe, Yuji Seki, Masafumi Int Med Case Rep J Case Series BACKGROUND: Mycobacterium abscessus frequently causes severe infections, yet its pathophysiological features and treatment regimens have not been established. CASE REPORT: We present five cases of severe pneumonia due to Mycobacterium abscessus infection in Japan. All cases were diabetic patients, with possible acceleration to pneumonia due to co-infection with other microorganisms. However, following a short period of hospitalization and combination therapy with intravenous imipenem/cilastatin and amikacin, all the cases were successfully treated as outpatients with oral clarithromycin and sitafloxacin. CONCLUSION: M. abscessus infections can become severe in the presence of diabetes mellitus and co-infection with other chronic infectious organisms. Sitafloxacin might be a key drug in the treatment of M. abscessus infection in future. Dove 2021-07-12 /pmc/articles/PMC8285566/ /pubmed/34285595 http://dx.doi.org/10.2147/IMCRJ.S321969 Text en © 2021 Takano et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Series
Takano, Kazuki
Shimada, Daishi
Kashiwagura, Shota
Kamioka, Yasuhiro
Hariu, Maya
Watanabe, Yuji
Seki, Masafumi
Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title_full Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title_fullStr Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title_full_unstemmed Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title_short Severe Pulmonary Mycobacterium abscessus Cases Due to Co-Infection with Other Microorganisms Well Treated by Clarithromycin and Sitafloxacin in Japan
title_sort severe pulmonary mycobacterium abscessus cases due to co-infection with other microorganisms well treated by clarithromycin and sitafloxacin in japan
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285566/
https://www.ncbi.nlm.nih.gov/pubmed/34285595
http://dx.doi.org/10.2147/IMCRJ.S321969
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